Reactome | HSPA8 [secretory granule lumen]

HSPA8 [secretory granule lumen]

Stable Identifier

R-SCE-6801530-2

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

secretory granule lumen

Synonyms

P10591

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P10591

Reference Genes

BioGPS Gene:851259

ENSEMBL:YAL005C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YAL005C

Monarch:851259

NCBI Gene:851259

SGD:YAL005C

Reference Transcript

RefSeq:NM_001178151.1

Other Identifiers

3LCA

4932.YAL005C

5LYN

AAC04952.1

CAA31393.1

DAA06982.1

EntrezGene:851259

EntrezGene:SSA1

GO:0000049

GO:0000060

GO:0000209

GO:0000329

GO:0002181

GO:0003674

GO:0003723

GO:0005524

GO:0005575

GO:0005576

GO:0005618

GO:0005634

GO:0005737

GO:0005773

GO:0005844

GO:0006457

GO:0006605

GO:0006616

GO:0006626

GO:0007005

GO:0008150

GO:0009277

GO:0015031

GO:0016020

GO:0016787

GO:0016887

GO:0035617

GO:0042026

GO:0043161

GO:0043167

GO:0051082

GO:0051603

GO:0055085

GO:0070647

GO:0072318

GO:0090344

IPR013126

IPR018181

IPR029047

IPR029048

NM_001178151.1

NP_009396.2

PF00012

PR00301

UPI0000168E53

YAL005C

YAL005C_mRNA

Participant Of

hasMember

Homologues of HSPA8 [secretory granule lumen]

Other forms of this molecule

HSPA8 [cytosol]

HSPA8 [nucleoplasm]

HSPA6 [ficolin-1-rich granule lumen]

HSPA1A [ficolin-1-rich granule lumen]

HSPA8 [ficolin-1-rich granule lumen]

HSPA1A [extracellular region]

HSPA6 [extracellular region]

HSPA8 [extracellular region]

HSPA6 [secretory granule lumen]

HSPA2 [nucleoplasm]

HSPA1L [nucleoplasm]

HSPA1A [nucleoplasm]

HSPA6 [nucleoplasm]

HSPA13 [nucleoplasm]

HSPA7 [nucleoplasm]

HSPA1L [cytosol]

HSPA2 [cytosol]

HSPA13 [cytosol]

HSPA6 [cytosol]

HSPA7 [cytosol]

HSPA1A [cytosol]

Me3K561-HSPA8 [nucleoplasm]

Inferred From

HSPA8 [secretory granule lumen] (Homo sapiens)

Cross References

RefSeq

NP_009396.2

PRO

P10591

PDB

3LCA, 5Z8Q, 5LYN, 5Z8I

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12118 SGT2	2	SGTA [cytosol] (R-SCE-5423595) SGT2 [cytosol] (R-SCE-9629049)	0.744	4
UniProt:P02829	11	HSP90AA1 [secretory granule lumen] (R-SCE-6801515) HSP90AB1 [secretory granule lumen] (R-SCE-6801477) HSP90AB1 [extracellular region] (R-SCE-6806463) HSP90AA1 [extracellular region] (R-SCE-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP90AB1 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP90AA1 [plasma membrane] (R-SCE-534996) HSP90AB1 [cytosol] (R-SCE-419617) HSP90AA1 [nucleoplasm] (R-SCE-5082401) HSP90AB1 [nucleoplasm] (R-SCE-5082399) HSP90AA1 [cytosol] (R-SCE-192864)	0.744	5
UniProt:P25294	3	DNAJB1 [cytosol] (R-SCE-3299666) phospho-p-S149,S151,S171 DNAJB1 [cytosol] (R-SCE-5690241) DNAJB1 [nucleoplasm] (R-SCE-5082366)	0.723	5
UniProt:P29547	1	EEF1G [cytosol] (R-SCE-156925)	0.643	3
UniProt:P14680	3	HIPK2 [nucleoplasm] (R-SCE-3215222) SUMO1-K32-HIPK2 [nucleoplasm] (R-SCE-4090405) HIPK1 [nucleoplasm] (R-SCE-3215224)	0.643	3
UniProt:Q08972	1	ABCF1 [cytosol] (R-SCE-5216139)	0.643	3
UniProt:P00546	5	CDK2 [nucleoplasm] (R-SCE-68365) phospho-p-T160-CDK2 [nucleoplasm] (R-SCE-187967) phospho-p-Y15-CDK2 [nucleoplasm] (R-SCE-187905) CDK2 [cytosol] (R-SCE-157440) phospho-p-CDK2 [nucleoplasm] (R-SCE-68370)	0.59	2
UniProt:P15303	4	SEC23A [endoplasmic reticulum membrane] (R-SCE-203976) phospho-p-S742,T747 SEC23A [cytosol] (R-SCE-5685740) SEC23A [cytosol] (R-SCE-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-SCE-204024)	0.527	2
UniProt:P38972	1	PFAS [cytosol] (R-SCE-62500)	0.527	2
UniProt:P32855	1	EXOC4 [plasma membrane] (R-SCE-264989)	0.527	2
UniProt:Q01217	1	NAGS(19-534) [mitochondrial matrix] (R-SCE-70528)	0.527	2
UniProt:P32324 EFT1	11	nascent EEF2 [cytosol] (R-SCE-5358472) Me3K525-EEF2 [cytosol] (R-SCE-8932237) aminocarboxypropyl EEF2 [cytosol] (R-SCE-5358478) diphthine EFT1 [cytosol] (R-SCE-5367015) Me-diphthine EFT1 [cytosol] (R-SCE-5367013) Me-diphthine EEF2 [cytosol] (R-SCE-5367025) EEF2 [ficolin-1-rich granule lumen] (R-SCE-6801513) EEF2 [extracellular region] (R-SCE-6806499) EEF2 [secretory granule lumen] (R-SCE-6801504) EEF2 [cytosol] (R-SCE-156901) diphthine EEF2 [cytosol] (R-SCE-5358501)	0.527	3
UniProt:P06786	4	TOP2B [nucleoplasm] (R-SCE-4641359) SUMO1-K-TOP2B [nucleoplasm] (R-SCE-4641297) SUMO1-K-TOP2A [nucleoplasm] (R-SCE-4641367) TOP2A [nucleoplasm] (R-SCE-1362276)	0.527	2
UniProt:P22147 XRN1	2	XRN1 [cytosol] (R-SCE-429835) XRN1_YEAST [cytosol] (R-SCE-429980)	0.527	2
UniProt:P36070	1	RRN3 [nucleoplasm] (R-SCE-73714)	0.527	2
UniProt:P12385 SUP45	3	Me-Q185-ETF1 [cytosol] (R-SCE-6800157) Erf-1 [cytosol] (R-SCE-141665) ETF1 [cytosol] (R-SCE-54433)	0.527	2
UniProt:P54837	7	phospho-MyrG-p-S16-TICAM2 [secretory granule membrane] (R-SCE-6804964) phospho-MyrG-p-S16-TICAM2 [plasma membrane] (R-SCE-166160) TMED10 [Golgi membrane] (R-SCE-6808801) TMED10 [transport vesicle] (R-SCE-6808802) TMED10 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SCE-5689845) TMED10 [endoplasmic reticulum membrane] (R-SCE-5689479) phospho-MyrG-p-S16-TICAM2 [endosome membrane] (R-SCE-2201336)	0.527	2
UniProt:P15705	1	STIP1 [cytosol] (R-SCE-443857)	0.527	2
UniProt:P40344	2	ATG3 [cytosol] (R-SCE-5671860) CysO263-ATG3 [cytosol] (R-SCE-5683569)	0.527	2
UniProt:P38931	1	SLC50A1 [plasma membrane] (R-SCE-5216211)	0.527	2
UniProt:P39935	2	EIF4G1 [cytosol] (R-SCE-72584) phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-SCE-165762)	0.527	2
UniProt:P29055	1	GTF2B [nucleoplasm] (R-SCE-65888)	0.527	2
UniProt:P22517	1	CAMK1 [cytosol] (R-SCE-9619207)	0.527	2
UniProt:Q01477	3	USP37 [nucleoplasm] (R-SCE-5697000) USP10 [nucleoplasm] (R-SCE-3222218) USP10 [cytosol] (R-SCE-6782974)	0.527	2
UniProt:P32471	2	EEF1D [cytosol] (R-SCE-156914) EEF1B2 [cytosol] (R-SCE-156926)	0.527	2
UniProt:Q00955	6	ACACA [cytosol] (R-SCE-1660609) phospho-Btn-p-S79-ACACB [mitochondrial outer membrane] (R-SCE-8876892-2) Btn-ACACA [cytosol] (R-SCE-2976730) ACACB [mitochondrial outer membrane] (R-SCE-4167505-2) Btn-ACACB [mitochondrial outer membrane] (R-SCE-2993858-2) ACACB [cytosol] (R-SCE-52493-2)	0.527	2
UniProt:Q12447	1	AANAT [cytosol] (R-SCE-209813)	0.527	2
UniProt:Q08920	2	NCBP2 [cytosol] (R-SCE-162458) NCBP2 [nucleoplasm] (R-SCE-51463)	0.527	2
UniProt:P43558	1	YOD1 [cytosol] (R-SCE-6781909)	0.527	3
UniProt:P16603	10	NOS1 [cytosol] (R-SCE-419293) NOS2 [peroxisomal matrix] (R-SCE-9033124) NOS2 [cytosol] (R-SCE-202107) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-SCE-535007) MyrG-NOS3 [Golgi membrane] (R-SCE-534995) NOS3 [cytosol] (R-SCE-202114) MyrG-NOS3 [cytosol] (R-SCE-203687) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-SCE-203769) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-SCE-534993) phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-SCE-202139)	0.527	2
UniProt:P02994	6	EEF1A1 [ficolin-1-rich granule lumen] (R-SCE-6801528) EEF1A1 [cytosol] (R-SCE-156905) EEF1A1 [extracellular region] (R-SCE-6806456) EEF1A1 [secretory granule lumen] (R-SCE-6801479) Me3K318-EEF1A1 [cytosol] (R-SCE-8932419) Me3K79-EEF1A1 [cytosol] (R-SCE-8932212)	0.527	2
UniProt:P25694	7	VCP [ficolin-1-rich granule lumen] (R-SCE-6800425) VCP [cytosol] (R-SCE-1181251) VCP [extracellular region] (R-SCE-6806191) VCP [secretory granule lumen] (R-SCE-6801039) VCP [azurophil granule lumen] (R-SCE-6800438) VCP [nucleoplasm] (R-SCE-5643745) Me3K315-VCP [cytosol] (R-SCE-8932209)	0.527	2
UniProt:Q04958	1	PNPLA6 [endoplasmic reticulum membrane] (R-SCE-1498821)	0.527	2
UniProt:P38431	1	EIF5 [cytosol] (R-SCE-72616)	0.527	2