Reactome | MCM5 [nucleoplasm]

MCM5 [nucleoplasm]

Stable Identifier

R-SCE-68551

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

P29496

Locations in the PathwayBrowser for interactor UniProt:P53840

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External Reference Information

External Reference

UniProt:P29496 MCM5

Gene Names

MCM5, CDC46, YLR274W, L9328.1

Chain

chain:1-775

Reference Genes

BioGPS Gene:850980 MCM5

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YLR274W MCM5

Monarch:850980 MCM5

NCBI Gene:850980 MCM5

Reference Transcript

RefSeq:NM_001182161.1 MCM5

Other Identifiers

10032_at

1771390_at

850980

GO:0000166

GO:0000347

GO:0000727

GO:0000781

GO:0000784

GO:0003674

GO:0003677

GO:0003678

GO:0003682

GO:0003688

GO:0003697

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005654

GO:0005656

GO:0005694

GO:0005737

GO:0006260

GO:0006267

GO:0006268

GO:0006270

GO:0006279

GO:0006281

GO:0006310

GO:0006325

GO:0006343

GO:0006348

GO:0006974

GO:0007049

GO:0008150

GO:0008270

GO:0016787

GO:0016887

GO:0017116

GO:0030174

GO:0031261

GO:0031298

GO:0031507

GO:0031509

GO:0031939

GO:0032200

GO:0032508

GO:0033260

GO:0042555

GO:0043138

GO:0043167

GO:0043596

GO:0051052

GO:0051321

GO:0071162

GO:0140657

Participates

as an output of

Mcm4,6,7 trimer forms and associates with the replication fork (Saccharomyces cerevisiae)

as an input of

MCM3 binds MCM5 (Saccharomyces cerevisiae)

as a component of

MCM3:MCM5 [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

yMcm5 [nucleoplasm]

Inferred From

MCM5 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_013376.1

OpenTargets

ENSG00000100297

PRO

P29496

PDB

7V3V, 7PMK, 5U8S, 6HV9, 6WGF, 5V8F, 6SKO, 6U0M, 7V3U, 8XGC, 7PMN, 7PT6, 3JC5, 7W8G, 6WGG, 5U8T, 8KG6, 7P5Z, 6PTJ, 3JA8, 6RQC, 3JC7, 6EYC, 6WGI, 7PT7, 5BK4, 3JC6, 8W7M, 8B9B, 8B9C, 6PTN, 6F0L, 8B9A, 6PTO, 5XF8, 6SKL, 7P30, 8KG8, 8W7S, 8KG9

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29469 MCM2	2	MCM2 [nucleoplasm] (R-SCE-68557) yMcm2 [nucleoplasm] (R-SCE-169497)	0.913	9
UniProt:P24279 MCM3	2	yMcm3 [nucleoplasm] (R-SCE-169513) MCM3 [nucleoplasm] (R-SCE-68546)	0.87	6
UniProt:Q08032	1	CDC45 [nucleoplasm] (R-SCE-68563)	0.731	5
UniProt:P30665 MCM4	2	yMcm4 [nucleoplasm] (R-SCE-169496) MCM4 [nucleoplasm] (R-SCE-68549)	0.725	8
UniProt:P53091 MCM6	2	yMcm6 [nucleoplasm] (R-SCE-169504) MCM6 [nucleoplasm] (R-SCE-68553)	0.643	3
UniProt:Q03406	1	SLD5 [nucleoplasm] (R-SCE-176963)	0.643	3
UniProt:P53840	1	TOF1 [nucleoplasm] (R-SCE-5684982)	0.643	3
UniProt:Q12146	1	PSF3 [nucleoplasm] (R-SCE-5688046)	0.564	2
UniProt:P43609	2	SMARCC1 [nucleoplasm] (R-SCE-389257) SMARCC2 [nucleoplasm] (R-SCE-389263-2)	0.527	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	4
UniProt:P11484	17	HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-4) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-4) HSPA1A [extracellular region] (R-SCE-6805872-4) HSPA6 [extracellular region] (R-SCE-6806500-4) HSPA6 [secretory granule lumen] (R-SCE-6801472-4) HSPA1L [cytosol] (R-SCE-3371410-4) HSPA2 [cytosol] (R-SCE-3371408-4) HSPA1A [cytosol] (R-SCE-6792602-4) HSPA1A [nucleoplasm] (R-SCE-6792605-4) HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA1L [nucleoplasm] (R-SCE-5082367-4) HSPA14 [nucleoplasm] (R-SCE-5252082-4) HSPA6 [nucleoplasm] (R-SCE-5252088-4) HSPA13 [nucleoplasm] (R-SCE-5252009-4) HSPA14 [cytosol] (R-SCE-5251948-4) HSPA13 [cytosol] (R-SCE-5251981-4) HSPA6 [cytosol] (R-SCE-3371521-4)	0.527	3
UniProt:Q01454 CTF4			0.527	3
UniProt:P38132 MCM7	2	yMcm7 [nucleoplasm] (R-SCE-169505) MCM7 [nucleoplasm] (R-SCE-68555)	0.527	2
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-4570518) HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-5423110) HHF2 [nucleoplasm] (R-SCE-5651652) HHF2 [nucleoplasm] (R-SCE-181902)	0.527	3
UniProt:P38144 ISW1			0.527	2
UniProt:P32354	1	MCM10 [nucleoplasm] (R-SCE-68403)	0.527	2
UniProt:P32558	1	SPT16 [nucleoplasm] (R-SCE-112415)	0.527	2
UniProt:Q04636	1	POB3 [nucleoplasm] (R-SCE-65105)	0.527	2
UniProt:Q12306	5	SMT3 [cytosol] (R-SCE-4656941) SMT3 [nucleoplasm] (R-SCE-3730622) SMT3 [nucleoplasm] (R-SCE-3730616) SMT3 [nucleoplasm] (R-SCE-877304) SMT3 [nucleoplasm] (R-SCE-2990831)	0.524	3
UniProt:P47112 TAH11	1	yCDT1 [nucleoplasm] (R-SCE-9749306)	0.495	3

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