Reactome | MCM2 [nucleoplasm]

MCM2 [nucleoplasm]

Stable Identifier

R-SCE-68557

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

MCM2, P29469

Locations in the PathwayBrowser for interactor UniProt:P32354"

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External Reference Information

External Reference

UniProt:P29469 MCM2

Gene Names

MCM2, YBL023C, YBL0438

Chain

chain:1-868

Reference Genes

BioGPS Gene:852258 MCM2

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YBL023C MCM2

Monarch:852258 MCM2

NCBI Gene:852258 MCM2

Reference Transcript

RefSeq:NM_001178263.1 MCM2

Other Identifiers

1776843_at

7384_at

852258

GO:0000278

GO:0000347

GO:0000727

GO:0003674

GO:0003677

GO:0003678

GO:0003682

GO:0003688

GO:0004386

GO:0005524

GO:0005575

GO:0005634

GO:0005654

GO:0005656

GO:0005694

GO:0005737

GO:0005829

GO:0006260

GO:0006267

GO:0006268

GO:0006270

GO:0006271

GO:0006281

GO:0006310

GO:0006974

GO:0008150

GO:0016787

GO:0016887

GO:0031261

GO:0031298

GO:0033043

GO:0042555

GO:0043167

GO:0046872

GO:0071162

GO:1902450

GO:1902975

GO:1905775

Participates

as an output of

Mcm4,6,7 trimer forms and associates with the replication fork (Saccharomyces cerevisiae)

as a component of

MCM2-7 [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

yMcm2 [nucleoplasm]

Inferred From

MCM2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_009530.1

OpenTargets

ENSG00000073111

PRO

P29469

PDB

5V8F, 6SKL, 5BK4, 5XF8, 6PTJ, 3JA8, 3JC7, 6U0M, 6WGI, 6HV9, 6WGF, 6F0L, 6PTO, 3JC5, 3JC6, 6WGG, 6PTN, 6RQC, 5U8S, 6EYC, 5U8T, 6SKO

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30665 MCM4	2	MCM4 [nucleoplasm] (R-SCE-68549) yMcm4 [nucleoplasm] (R-SCE-169496)	0.939	15
UniProt:P29496 MCM5	2	yMcm5 [nucleoplasm] (R-SCE-169511) MCM5 [nucleoplasm] (R-SCE-68551)	0.879	8
UniProt:P24279 MCM3	2	MCM3 [nucleoplasm] (R-SCE-68546) yMcm3 [nucleoplasm] (R-SCE-169513)	0.855	8
UniProt:P53091 MCM6	2	MCM6 [nucleoplasm] (R-SCE-68553) yMcm6 [nucleoplasm] (R-SCE-169504)	0.839	7
UniProt:P38132 MCM7	2	MCM7 [nucleoplasm] (R-SCE-68555) yMcm7 [nucleoplasm] (R-SCE-169505)	0.839	7
UniProt:Q08032	1	CDC45 [nucleoplasm] (R-SCE-68563)	0.731	4
UniProt:P09119	4	phospho-CDC6 [cytosol] (R-SCE-68583) CDC6 [cytosol] (R-SCE-113566) phospho-CDC6 [nucleoplasm] (R-SCE-5661317) CDC6 [nucleoplasm] (R-SCE-68542)	0.667	4
UniProt:P47112 CDT1			0.638	4
UniProt:Q08496 DIA2			0.613	4
UniProt:P11484 SSB1			0.564	2
UniProt:P32354	1	MCM10 [nucleoplasm] (R-SCE-68403)	0.547	2
UniProt:Q12306	31	SMT3 [nucleoplasm] (R-SCE-3968375) SMT3 [nucleoplasm] (R-SCE-4085334) SMT3 [nuclear envelope] (R-SCE-4551627) SMT3 [nucleoplasm] (R-SCE-4086096) SMT3 [nucleoplasm] (R-SCE-3900210) SMT3 [nucleoplasm] (R-SCE-3900212) SMT3 [nucleoplasm] (R-SCE-4086058) SMT3 [nucleoplasm] (R-SCE-4090362) SMT3 [nucleoplasm] (R-SCE-4641311) SMT3 [nucleoplasm] (R-SCE-4641306) SMT3 [nucleoplasm] (R-SCE-4641341) SMT3 [nucleoplasm] (R-SCE-4615836) SMT3 [nucleoplasm] (R-SCE-3826645) SMT3 [nucleoplasm] (R-SCE-3826574) SMT3 [nucleoplasm] (R-SCE-4568857) SMT3 [nucleoplasm] (R-SCE-4570452) SMT3 [nucleoplasm] (R-SCE-3730731) SMT3 [nucleoplasm] (R-SCE-3730738) SMT3 [nucleoplasm] (R-SCE-3968396) SMT3 [nucleoplasm] (R-SCE-4570515) SMT3 [nucleoplasm] (R-SCE-4570462) SMT3 [nucleoplasm] (R-SCE-4616028) SMT3 [nucleoplasm] (R-SCE-4616032) SMT3 [nucleoplasm] (R-SCE-4615961) SMT3 [nucleoplasm] (R-SCE-4615956) SMT3 [nucleoplasm] (R-SCE-4570549) SMT3 [nucleoplasm] (R-SCE-3730796) SMT3 [nucleoplasm] (R-SCE-2990831) SMT3 [nucleoplasm] (R-SCE-877304) SMT3 [nucleoplasm] (R-SCE-3730616) SMT3 [nucleoplasm] (R-SCE-3730622)	0.524	2

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