Reactome | CDC45 [nucleoplasm]

CDC45 [nucleoplasm]

Stable Identifier

R-SCE-68563

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

CDC45, Q08032

Locations in the PathwayBrowser for interactor UniProt:P25588

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External Reference Information

External Reference

UniProt:Q08032

Gene Names

CDC45

Reference Genes

BioGPS Gene:850793 CDC45

ENSEMBL:YLR103C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YLR103C CDC45

Monarch:850793 CDC45

NCBI Gene:850793 CDC45

SGD:YLR103C

Reference Transcript

RefSeq:NM_001181990.1 CDC45

Other Identifiers

10222_at

1771269_at

850793

GO:0000278

GO:0000727

GO:0003674

GO:0003677

GO:0003682

GO:0003688

GO:0003697

GO:0004386

GO:0005515

GO:0005575

GO:0005634

GO:0005656

GO:0005694

GO:0006260

GO:0006267

GO:0006268

GO:0006270

GO:0006281

GO:0006310

GO:0006974

GO:0007049

GO:0008150

GO:0031261

GO:0031298

GO:0031938

GO:0043138

GO:0043596

GO:0051726

GO:0071162

GO:0140657

GO:1900087

GO:1902977

Participates

as an input of

Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)

as a component of

CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Saccharomyces cerevisiae)

Inferred From

CDC45 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_013204.1

OpenTargets

ENSG00000093009

PRO

Q08032

PDB

5U8S, 3JC6, 3JC7, 5U8T, 8W7S, 6PTO, 8KG9, 6PTN, 6SKL, 6U0M, 8W7M, 8KG8, 3JC5, 6HV9, 8XGC, 8KG6, 6PTJ, 7QHS

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53135 SLD3			0.861	13
UniProt:Q03406	1	SLD5 [nucleoplasm] (R-SCE-176963)	0.841	8
UniProt:P53091 MCM6	2	yMcm6 [nucleoplasm] (R-SCE-169504) MCM6 [nucleoplasm] (R-SCE-68553)	0.793	5
UniProt:P29469 MCM2	2	MCM2 [nucleoplasm] (R-SCE-68557) yMcm2 [nucleoplasm] (R-SCE-169497)	0.793	5
UniProt:P30665 MCM4	2	yMcm4 [nucleoplasm] (R-SCE-169496) MCM4 [nucleoplasm] (R-SCE-68549)	0.793	8
UniProt:P24279 MCM3	2	yMcm3 [nucleoplasm] (R-SCE-169513) MCM3 [nucleoplasm] (R-SCE-68546)	0.731	4
UniProt:P29496 MCM5	2	yMcm5 [nucleoplasm] (R-SCE-169511) MCM5 [nucleoplasm] (R-SCE-68551)	0.731	5
UniProt:P25588	5	MRC1 [nucleoplasm] (R-SCE-6783087) MRC1 [nucleoplasm] (R-SCE-351929) MRC1 [nucleoplasm] (R-SCE-351935) MRC1 [nucleoplasm] (R-SCE-176282) phospho-MRC1 [nucleoplasm] (R-SCE-176296)	0.688	4
UniProt:P38132 MCM7	2	yMcm7 [nucleoplasm] (R-SCE-169505) MCM7 [nucleoplasm] (R-SCE-68555)	0.648	3
UniProt:P53840	1	TOF1 [nucleoplasm] (R-SCE-5684982)	0.564	3
UniProt:P32354	1	MCM10 [nucleoplasm] (R-SCE-68403)	0.564	2
UniProt:Q12488	1	PSF1 [nucleoplasm] (R-SCE-176955)	0.528	2
UniProt:Q12146	1	PSF3 [nucleoplasm] (R-SCE-5688046)	0.528	2
UniProt:P32561	4	RPD3 [nucleoplasm] (R-SCE-205135) RPD3 [nucleoplasm] (R-SCE-205021) RPD3 [nucleoplasm] (R-SCE-4615958) RPD3 [nucleoplasm] (R-SCE-4616030)	0.527	2
UniProt:P13382	1	POLA1 [nucleoplasm] (R-SCE-68487)	0.527	2
UniProt:P22579	3	SIN3 [nucleoplasm] (R-SCE-4086071) SIN3 [nucleoplasm] (R-SCE-351657) SIN3 [nucleoplasm] (R-SCE-349685)	0.527	2
UniProt:Q01454 CTF4			0.527	3
UniProt:P40495 LYS12			0.527	2

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