Reactome | RPP0 [cytosol]

RPP0 [cytosol]

Stable Identifier

R-SCE-72396

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

RPLP0, P05317

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPP0 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPP0 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPP0 [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPP0 [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPP0 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P05317

Gene Names

RPP0

Reference Genes

BioGPS Gene:851052 RPP0

ENSEMBL:YLR340W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YLR340W RPP0

Monarch:851052 RPP0

NCBI Gene:851052 RPP0

SGD:YLR340W

Reference Transcript

RefSeq:NM_001182229.1 RPP0

Other Identifiers

1778794_at

851052

9964_at

GO:0000027

GO:0002181

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005737

GO:0005840

GO:0008150

GO:0019843

GO:0022625

GO:0030686

GO:0042254

GO:0042255

GO:0042273

GO:0070180

GO:0070925

GO:1990904

Participates

as a component of

Inferred From

RPLP0 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_013444.1

PRO

P05317

PDB

4U4Z, 8AAF, 6GQ1, 4U4N, 5DAT, 4U55, 4U51, 4U4Y, 3J77, 5TGA, 4U53, 4V8Z, 6I7O, 5APO, 8AGT, 5JUS, 3J16, 8AGU, 8CDL, 4V8T, 8EVQ, 7TOO, 5JUP, 4U4R, 8CMJ, 5APN, 4U3U, 7U6V, 8AGW, 6GQB, 5FCJ, 5MEI, 8CKU, 5I4L, 8AGX, 4U3N, 6WOO, 4U3M, 8CG8, 4V6I, 4U56, 4U4O, 4U6F, 8CEH, 6OIG, 5JUU, 5NDG, 4U52, 5DGF, 4V7R, 5JUT, 6T83, 4V8Y, 3J78, 5LYB, 5ON6, 4U50, 5DGE, 8CF5, 6HHQ, 5TBW, 8EUB, 4U4U, 8CGN, 8AGV, 7TOP, 8EVR, 6SV4, 5JUO, 8CDR, 8EVS, 8CIV, 5DC3, 6R84, 6GQV, 4U4Q, 6R86, 8AGZ, 5FCI, 5DGV, 5TGM, 8EWB, 5OBM, 8CCS, 6R87, 4V88

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32324 EFT1	11	Me3K525-EEF2 [cytosol] (R-SCE-8932237) diphthine EFT1 [cytosol] (R-SCE-5367015) Me-diphthine EFT1 [cytosol] (R-SCE-5367013) diphthine EEF2 [cytosol] (R-SCE-5358501) nascent EEF2 [cytosol] (R-SCE-5358472) Me-diphthine EEF2 [cytosol] (R-SCE-5367025) aminocarboxypropyl EEF2 [cytosol] (R-SCE-5358478) EEF2 [cytosol] (R-SCE-156901) EEF2 [secretory granule lumen] (R-SCE-6801504) EEF2 [ficolin-1-rich granule lumen] (R-SCE-6801513) EEF2 [extracellular region] (R-SCE-6806499)	0.622	3
UniProt:Q01477	2	UBP3 [cytosol] (R-SCE-6782974) UBP3 [nucleoplasm] (R-SCE-3222218)	0.527	2
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-4570518) HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-5423110) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-5651652) HHF2 [nucleoplasm] (R-SCE-181902)	0.527	3