Reactome | SYP1 [cytosol]

SYP1 [cytosol]

Stable Identifier

R-SCE-8862260

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

FCHO2, P25623

Locations in the PathwayBrowser

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Vesicle-mediated transport (Saccharomyces cerevisiae)

- Membrane Trafficking (Saccharomyces cerevisiae)
  - Clathrin-mediated endocytosis (Saccharomyces cerevisiae)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Saccharomyces cerevisiae)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Saccharomyces cerevisiae)
        
        FCHO1,2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        FCHO2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        SYP1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Saccharomyces cerevisiae)
        
        FCHO1,2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        FCHO2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        SYP1 [cytosol] (Saccharomyces cerevisiae)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Saccharomyces cerevisiae)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Saccharomyces cerevisiae)
        
        FCHO1,2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        FCHO2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        SYP1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Saccharomyces cerevisiae)
        
        FCHO1,2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        FCHO2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        SYP1 [cytosol] (Saccharomyces cerevisiae)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Saccharomyces cerevisiae)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Saccharomyces cerevisiae)
        
        FCHO1,2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        FCHO2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        SYP1 [cytosol] (Saccharomyces cerevisiae)
    - FCHo proteins bind nascent clathrin-coated pit (Saccharomyces cerevisiae)
      - FCHO1,2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        FCHO2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        SYP1 [cytosol] (Saccharomyces cerevisiae)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Saccharomyces cerevisiae)
        
        FCHO1,2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        FCHO2 dimer [cytosol] (Saccharomyces cerevisiae)
        
        SYP1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P25623

Gene Names

SYP1

Reference Genes

BioGPS Gene:850396 SYP1

ENSEMBL:YCR030C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YCR030C SYP1

Monarch:850396 SYP1

NCBI Gene:850396 SYP1

SGD:YCR030C

Reference Transcript

RefSeq:NM_001178744.1 SYP1

Other Identifiers

1774066_at

6865_at

GO:0000144

GO:0000147

GO:0001400

GO:0003674

GO:0004857

GO:0005575

GO:0005737

GO:0005856

GO:0005933

GO:0005934

GO:0005935

GO:0005938

GO:0006897

GO:0007010

GO:0007049

GO:0008150

GO:0030234

GO:0030427

GO:0032185

GO:0042802

GO:0043086

GO:0061645

Participant Of

hasComponent

FCHO2 dimer [cytosol]

Other forms of this molecule

SYP1 [cytosol]

Inferred From

FCHO2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_009959.2

PRO

P25623

PDB

3G9H, 3G9G

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34216	4	EDE1 [cytosol] (R-SCE-8862264-3) EDE1 [cytosol] (R-SCE-8862265-3) EDE1 [cytosol] (R-SCE-182920-3) EDE1 [cytosol] (R-SCE-3006481-3)	0.808	8
UniProt:P25623	3	SYP1 [cytosol] (R-SCE-8862260) SYP1 [cytosol] (R-SCE-8862268) SYP1 [cytosol] (R-SCE-8862257)	0.592	2
UniProt:P36027 MID2			0.573	2
UniProt:P43603 LSB3			0.553	2
UniProt:P32790	4	SLA1 [cytosol] (R-SCE-8862264-2) SLA1 [cytosol] (R-SCE-8862265-2) SLA1 [cytosol] (R-SCE-182920-2) SLA1 [cytosol] (R-SCE-3006481-2)	0.547	2
UniProt:P22517	1	CMK2 [cytosol] (R-SCE-9619207)	0.527	2