Reactome | FBXL13 [cytosol]

FBXL13 [cytosol]

Stable Identifier

R-SCE-8862616

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

Q06479

Locations in the PathwayBrowser

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Immune System (Saccharomyces cerevisiae)

- Adaptive Immune System (Saccharomyces cerevisiae)
  - Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
    - Antigen processing: Ubiquitination & Proteasome degradation (Saccharomyces cerevisiae)
      - Release of E3 from polyubiquitinated substrate (Saccharomyces cerevisiae)
        
        E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXL13 [cytosol] (Saccharomyces cerevisiae)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Saccharomyces cerevisiae)
        
        E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXL13 [cytosol] (Saccharomyces cerevisiae)
      - Transfer of Ub from E2 to substrate and release of E2 (Saccharomyces cerevisiae)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Saccharomyces cerevisiae)
        
        E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXL13 [cytosol] (Saccharomyces cerevisiae)
        
        E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXL13 [cytosol] (Saccharomyces cerevisiae)
        
        E3:Ub:substrate [cytosol] (Saccharomyces cerevisiae)
        
        E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXL13 [cytosol] (Saccharomyces cerevisiae)

Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - Neddylation (Saccharomyces cerevisiae)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Saccharomyces cerevisiae)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Saccharomyces cerevisiae)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Saccharomyces cerevisiae)
        
        SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXL13 [cytosol] (Saccharomyces cerevisiae)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Saccharomyces cerevisiae)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Saccharomyces cerevisiae)
        
        F-box protein [cytosol] (Saccharomyces cerevisiae)
        
        FBXL13 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:Q06479

Reference Genes

BioGPS Gene:851066

ENSEMBL:YLR352W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YLR352W

Monarch:851066

NCBI Gene:851066

SGD:YLR352W

Reference Transcript

RefSeq:NM_001182241.1

Other Identifiers

1772921_at

851066

9976_at

GO:0005575

GO:0008150

GO:0016567

GO:0019005

GO:0070647

Participant Of

hasMember

F-box protein [cytosol]

Other forms of this molecule

FBXL20 [cytosol]

FBXL15 [cytosol]

FBXL14 [cytosol]

FBXL4 [cytosol]

PolyUb-K109-FBXL7 [cytosol]

FBXL7 [cytosol]

Inferred From

FBXL13 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_013456.1

PRO

Q06479

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52286	2	SKP1 [nucleoplasm] (R-SCE-187538) SKP1 [cytosol] (R-SCE-174150)	0.659	3
UniProt:Q12018	4	CDC53 [cytosol] (R-SCE-180528) CDC53 [cytosol] (R-SCE-8952519) CDC53 [nucleoplasm] (R-SCE-187551) CDC53 [cytosol] (R-SCE-174230)	0.643	4