Reactome | FAL1 [cytosol]

FAL1 [cytosol]

Stable Identifier

R-SCE-927868

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

EIF4A3, Q12099

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Saccharomyces cerevisiae)
        
        FAL1 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Saccharomyces cerevisiae)
        
        FAL1 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Saccharomyces cerevisiae)
        
        FAL1 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:Q12099

Gene Names

FAL1

Reference Genes

BioGPS Gene:851584 FAL1

ENSEMBL:YDR021W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDR021W FAL1

Monarch:851584 FAL1

NCBI Gene:851584 FAL1

SGD:YDR021W

Reference Transcript

RefSeq:NM_001180329.3 FAL1

Other Identifiers

1776348_at

6436_at

851584

GO:0000462

GO:0003674

GO:0003676

GO:0003723

GO:0004004

GO:0005524

GO:0005575

GO:0005634

GO:0005730

GO:0005737

GO:0006364

GO:0008150

GO:0008380

GO:0010468

GO:0010501

GO:0030688

GO:0042274

GO:0043167

GO:0071013

GO:0097078

Participant Of

hasComponent

Core Exon Junction Complex (Core EJC) [cytosol]

Inferred From

EIF4A3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_010304.3

IntEnz

3.6.4.13

PRO

Q12099

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