Reactome | bub3 [cytosol]

bub3 [cytosol]

Stable Identifier

R-SPO-141416

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

BUB3, O42860

Locations in the PathwayBrowser

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Cell Cycle (Schizosaccharomyces pombe)

- Cell Cycle Checkpoints (Schizosaccharomyces pombe)
  - Mitotic Spindle Checkpoint (Schizosaccharomyces pombe)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Schizosaccharomyces pombe)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Schizosaccharomyces pombe)
        
        Formation of the MCC complex (Schizosaccharomyces pombe)
        
        bub3 [cytosol] (Schizosaccharomyces pombe)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Schizosaccharomyces pombe)
        
        bub3 [cytosol] (Schizosaccharomyces pombe)
- Cell Cycle, Mitotic (Schizosaccharomyces pombe)
  - Regulation of mitotic cell cycle (Schizosaccharomyces pombe)
    - APC/C-mediated degradation of cell cycle proteins (Schizosaccharomyces pombe)
      - Regulation of APC/C activators between G1/S and early anaphase (Schizosaccharomyces pombe)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Schizosaccharomyces pombe)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Schizosaccharomyces pombe)
        
        Formation of the MCC complex (Schizosaccharomyces pombe)
        
        bub3 [cytosol] (Schizosaccharomyces pombe)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Schizosaccharomyces pombe)
        
        bub3 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:O42860

Gene Names

bub3

Reference Genes

BioGPS Gene:2541856 bub3

ENSEMBL:SPAC23H3.08c

GeneDB:SPAC23H3.08c

KEGG Gene (Schizosaccharomyces pombe):SPAC23H3.08c bub3

Monarch:2541856 bub3

NCBI Gene:2541856 bub3

Reference Transcript

RefSeq:NM_001019227.2 bub3

Participates

as an input of

Formation of the MCC complex (Schizosaccharomyces pombe)

as a component of

hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Schizosaccharomyces pombe)

Inferred From

BUB3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_593798.1

PRO

O42860

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