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phospho-p-T308,S473-AKT1 [cytosol]
Stable Identifier
R-SPO-198356-2
Type
Protein [EntityWithAccessionedSequence]
Species
Schizosaccharomyces pombe
Compartment
cytosol
Synonyms
Q10364
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Schizosaccharomyces pombe)
RNA Polymerase II Transcription (Schizosaccharomyces pombe)
Generic Transcription Pathway (Schizosaccharomyces pombe)
Transcriptional Regulation by TP53 (Schizosaccharomyces pombe)
TP53 Regulates Metabolic Genes (Schizosaccharomyces pombe)
AKT phosphorylates TSC2, inhibiting it (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Immune System (Schizosaccharomyces pombe)
Adaptive Immune System (Schizosaccharomyces pombe)
Costimulation by the CD28 family (Schizosaccharomyces pombe)
CTLA4 inhibitory signaling (Schizosaccharomyces pombe)
Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Metabolism (Schizosaccharomyces pombe)
Metabolism of nitric oxide: NOS3 activation and regulation (Schizosaccharomyces pombe)
eNOS activation (Schizosaccharomyces pombe)
AKT1 binds eNOS complex via HSP90 (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of cofactors (Schizosaccharomyces pombe)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Schizosaccharomyces pombe)
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Metabolism of RNA (Schizosaccharomyces pombe)
Regulation of mRNA stability by proteins that bind AU-rich elements (Schizosaccharomyces pombe)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Schizosaccharomyces pombe)
Protein Kinase B/Akt phosphorylates BRF1 (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Signal Transduction (Schizosaccharomyces pombe)
Intracellular signaling by second messengers (Schizosaccharomyces pombe)
PIP3 activates AKT signaling (Schizosaccharomyces pombe)
AKT phosphorylates targets in the cytosol (Schizosaccharomyces pombe)
AKT phosphorylates MKRN1 (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
AKT phosphorylates TSC2, inhibiting it (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Negative regulation of the PI3K/AKT network (Schizosaccharomyces pombe)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Schizosaccharomyces pombe)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
PTEN Regulation (Schizosaccharomyces pombe)
Regulation of PTEN stability and activity (Schizosaccharomyces pombe)
AKT phosphorylates MKRN1 (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Signaling by Nuclear Receptors (Schizosaccharomyces pombe)
ESR-mediated signaling (Schizosaccharomyces pombe)
Extra-nuclear estrogen signaling (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Signaling by Receptor Tyrosine Kinases (Schizosaccharomyces pombe)
Signaling by ERBB2 (Schizosaccharomyces pombe)
Downregulation of ERBB2 signaling (Schizosaccharomyces pombe)
Downregulation of ERBB2:ERBB3 signaling (Schizosaccharomyces pombe)
Phosphorylation of USP8 by P-AKT (Schizosaccharomyces pombe)
p-T,p-S-AKT [cytosol] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Signaling by VEGF (Schizosaccharomyces pombe)
VEGFA-VEGFR2 Pathway (Schizosaccharomyces pombe)
VEGFR2 mediated vascular permeability (Schizosaccharomyces pombe)
AKT1 binds eNOS complex via HSP90 (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
External Reference Information
External Reference
UniProt:Q10364
Reference Genes
BioGPS Gene:2541867
ENSEMBL:SPAC22E12.14c
GeneDB:SPAC22E12.14c
KEGG Gene (Schizosaccharomyces pombe):SPAC22E12.14c
Monarch:2541867
NCBI Gene:2541867
Reference Transcript
RefSeq:NM_001020269.2
Participates
as a member of
Homologues of p-T308,S473-AKT1 [cytosol] (Schizosaccharomyces pombe)
Other forms of this molecule
phospho-p-T308,S473-AKT1 [plasma membrane]
phospho-p-T308-AKT1 [cytosol]
phospho-p-T305-AKT3 [cytosol]
phospho-p-T309-AKT2 [cytosol]
SGK1 [cytosol]
phospho-p-S422-SGK1 [cytosol]
phospho-p-T256,S422-SGK1 [cytosol]
phospho-p-T256,S422-SGK1 [nucleoplasm]
AKT1 [cytosol]
AKT3 [cytosol]
AKT2 [cytosol]
AKT1 [plasma membrane]
AKT3 [plasma membrane]
AKT2 [plasma membrane]
phospho-p-S473-AKT1 [plasma membrane]
phospho-p-S472-AKT3 [plasma membrane]
phospho-p-S474-AKT2 [plasma membrane]
phospho-p-T309,S474-AKT2 [cytosol]
phospho-p-T305,S472-AKT3 [cytosol]
phospho-p-T308,S473-AKT1 [nucleoplasm]
phospho-p-T305,S472-AKT3 [nucleoplasm]
phospho-p-T309,S474-AKT2 [nucleoplasm]
Inferred From
p-T308,S473-AKT1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 308 (in Homo sapiens)
Coordinate
308
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 473 (in Homo sapiens)
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_594840.1
PRO
Q10364
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