Reactome | rad32 [nucleoplasm]

rad32 [nucleoplasm]

Stable Identifier

R-SPO-59544

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Synonyms

MRE11A, Q09683

Locations in the PathwayBrowser

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DNA Repair (Schizosaccharomyces pombe)

- DNA Double-Strand Break Repair (Schizosaccharomyces pombe)
  - DNA Double Strand Break Response (Schizosaccharomyces pombe)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Schizosaccharomyces pombe)
      - ATM phosphorylates HERC2 (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - ATM phosphorylates MDC1 (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - ATM phosphorylates NBN (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - ATM phosphorylates TP53BP1 at DNA DSBs (Schizosaccharomyces pombe)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - ATM phosphorylates WHSC1 (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - ATM recognizes H2AFX-Nucleosomes (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - PPP5C dephosphorylates TP53BP1 (Schizosaccharomyces pombe)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - RNF8 and RNF168 ubiquitinate H2AFX (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - RNF8 binds phosphorylated MDC1 at DNA DSBs (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - TP53BP1 associates with H4K20Me2 at DNA DSBs (Schizosaccharomyces pombe)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - WHSC1 binds DNA DSBs (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
    - Sensing of DNA Double Strand Breaks (Schizosaccharomyces pombe)
      - Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        RAD50:MRE11A [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - Formation of RAD50:MRE11 complex (Schizosaccharomyces pombe)
        
        RAD50:MRE11A [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - KAT5 acetylates ATM at DNA DSBs (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - MRN activates ATM (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - MRN complex binds DNA double strand breaks (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - MRN complex bound to DNA ends recruits ATM (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
  - Homology Directed Repair (Schizosaccharomyces pombe)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Schizosaccharomyces pombe)
      - Processing of DNA double-strand break ends (Schizosaccharomyces pombe)
        
        ATM phosphorylates RBBP8 (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S327,T847,T859-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        CDK2 phosphorylates RBBP8 (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
    - HDR through MMEJ (alt-NHEJ) (Schizosaccharomyces pombe)
      - FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)
        
        Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
      - MRN and RBBP8 resect DNA DSBs in MMEJ (Schizosaccharomyces pombe)
        
        DNA DSB:MRN:RBBP8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        MRN [nucleoplasm] (Schizosaccharomyces pombe)
        
        rad32 [nucleoplasm] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:Q09683

Gene Names

rad32

Reference Genes

BioGPS Gene:2542757 rad32

ENSEMBL:SPAC13C5.07

GeneDB:SPAC13C5.07

KEGG Gene (Schizosaccharomyces pombe):SPAC13C5.07 rad32

Monarch:2542757 rad32

NCBI Gene:2542757 rad32

Reference Transcript

RefSeq:NM_001018336.2 rad32

Participates

as a component of

as an input of

Formation of RAD50:MRE11 complex (Schizosaccharomyces pombe)

Other forms of this molecule

rad32 [cytosol]

Inferred From

MRE11A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_592935.1

PRO

Q09683

PDB

4FBQ, 4FCX, 4FBW, 4FBK

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43070	2	nbs1 [nucleoplasm] (R-SPO-75163) phospho-nbs1 [nucleoplasm] (R-SPO-75237)	0.743	6
UniProt:Q9UTJ8	1	RAD50 [nucleoplasm] (R-SPO-75160)	0.553	2
UniProt:Q09683	2	rad32 [cytosol] (R-SPO-3204309) rad32 [nucleoplasm] (R-SPO-59544)	0.553	2

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