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crb2 [nucleoplasm]
Stable Identifier
R-SPO-61175
Type
Protein [EntityWithAccessionedSequence]
Species
Schizosaccharomyces pombe
Compartment
nucleoplasm
Synonyms
TP53BP1, P87074
Locations in the PathwayBrowser
Expand all
DNA Repair (Schizosaccharomyces pombe)
DNA Double-Strand Break Repair (Schizosaccharomyces pombe)
DNA Double Strand Break Response (Schizosaccharomyces pombe)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Schizosaccharomyces pombe)
ATM phosphorylates TP53BP1 at DNA DSBs (Schizosaccharomyces pombe)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
crb2 [nucleoplasm] (Schizosaccharomyces pombe)
PPP5C dephosphorylates TP53BP1 (Schizosaccharomyces pombe)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
crb2 [nucleoplasm] (Schizosaccharomyces pombe)
TP53BP1 associates with H4K20Me2 at DNA DSBs (Schizosaccharomyces pombe)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
crb2 [nucleoplasm] (Schizosaccharomyces pombe)
crb2 [nucleoplasm] (Schizosaccharomyces pombe)
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
SUMOylation (Schizosaccharomyces pombe)
SUMO E3 ligases SUMOylate target proteins (Schizosaccharomyces pombe)
SUMOylation of transcription factors (Schizosaccharomyces pombe)
PIAS4 SUMOylates TP53BP1 with SUMO1 (Schizosaccharomyces pombe)
crb2 [nucleoplasm] (Schizosaccharomyces pombe)
External Reference Information
External Reference
UniProt:P87074
Gene Names
crb2
Reference Genes
BioGPS Gene:2540992 crb2
ENSEMBL:SPBC342.05
GeneDB:SPBC342.05
KEGG Gene (Sc):SPBC342.05 crb2
Monarch:2540992 crb2
NCBI Gene:2540992 crb2
Reference Transcript
RefSeq:NM_001023768.2 crb2
Participant Of
input
PIAS4 SUMOylates TP53BP1 with SUMO1
TP53BP1 associates with H4K20Me2 at DNA DSBs
hasComponent
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm]
Other forms of this molecule
crb2 [nucleoplasm]
phospho-crb2 [nucleoplasm]
Inferred From
TP53BP1 [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_596748.1
PRO
P87074
PDB
4BU0
,
4BU1
,
2FHD
,
2VXC
,
2VXB
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P34208 chk1
1
CHK1 (POMBE) [nucleoplasm]
(R-SPO-75038)
0.658
4
UniProt:P32372 RAD4
0.573
2
UniProt:P87074
3
crb2 [nucleoplasm]
(R-SPO-61175)
crb2 [nucleoplasm]
(R-SPO-2997591)
phospho-crb2 [nucleoplasm]
(R-SPO-5683418)
0.508
3
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