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tif471 [cytosol]
Stable Identifier
R-SPO-72584
Type
Protein [EntityWithAccessionedSequence]
Species
Schizosaccharomyces pombe
Compartment
cytosol
Synonyms
EIF4G1, Q10475
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Schizosaccharomyces pombe)
Nonsense-Mediated Decay (NMD) (Schizosaccharomyces pombe)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
mRNA Cleaved by SMG6 [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Schizosaccharomyces pombe)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
Metabolism of proteins (Schizosaccharomyces pombe)
Translation (Schizosaccharomyces pombe)
Eukaryotic Translation Initiation (Schizosaccharomyces pombe)
Cap-dependent Translation Initiation (Schizosaccharomyces pombe)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Schizosaccharomyces pombe)
Cap-bound mRNA is activated by helicases (Schizosaccharomyces pombe)
eIF4F:mRNP [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
Formation of the cap-binding eIF4F complex (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
Translation initiation complex formation (Schizosaccharomyces pombe)
Formation of translation initiation complexes containing mRNA that does not circularize (Schizosaccharomyces pombe)
48S complex [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
GTP hydrolysis and joining of the 60S ribosomal subunit (Schizosaccharomyces pombe)
eIF2:GTP is hydrolyzed, eIFs are released (Schizosaccharomyces pombe)
48S complex [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
Ribosomal scanning and start codon recognition (Schizosaccharomyces pombe)
Ribosomal scanning (Schizosaccharomyces pombe)
48S complex [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
Start codon recognition (Schizosaccharomyces pombe)
48S complex [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
L13a-mediated translational silencing of Ceruloplasmin expression (Schizosaccharomyces pombe)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Schizosaccharomyces pombe)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Schizosaccharomyces pombe)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
Signal Transduction (Schizosaccharomyces pombe)
MTOR signalling (Schizosaccharomyces pombe)
mTORC1-mediated signalling (Schizosaccharomyces pombe)
Phosphorylation and activation of eIF4G by activated S6K1 (Schizosaccharomyces pombe)
tif471 [cytosol] (Schizosaccharomyces pombe)
External Reference Information
External Reference
UniProt:Q10475
Gene Names
tif471
Reference Genes
BioGPS Gene:2542290 tif471
ENSEMBL:SPAC17C9.03
GeneDB:SPAC17C9.03
KEGG Gene (Schizosaccharomyces pombe):SPAC17C9.03 tif471
Monarch:2542290 tif471
NCBI Gene:2542290 tif471
Reference Transcript
RefSeq:NM_001020030.2 tif471
Participates
as a component of
mRNA Cleaved by SMG6 [cytosol] (Schizosaccharomyces pombe)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Schizosaccharomyces pombe)
as an output of
eIF2:GTP is hydrolyzed, eIFs are released (Schizosaccharomyces pombe)
as an input of
Formation of the cap-binding eIF4F complex (Schizosaccharomyces pombe)
Phosphorylation and activation of eIF4G by activated S6K1 (Schizosaccharomyces pombe)
Other forms of this molecule
phospho-tif471 [cytosol]
Inferred From
EIF4G1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_594602.1
PRO
Q10475
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