Reactome | Homologues of p-S140-H2AFX [nucleoplasm]

Homologues of p-S140-H2AFX [nucleoplasm]

Stable Identifier

R-SPO-75170-3

Type

Set [DefinedSet]

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Locations in the PathwayBrowser

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DNA Repair (Schizosaccharomyces pombe)

- DNA Double-Strand Break Repair (Schizosaccharomyces pombe)
  - DNA Double Strand Break Response (Schizosaccharomyces pombe)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Schizosaccharomyces pombe)
      - ATM phosphorylates HERC2 (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
      - ATM phosphorylates MDC1 (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
      - ATM phosphorylates WHSC1 (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
      - RNF8 and RNF168 ubiquitinate H2AFX (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
      - RNF8 binds phosphorylated MDC1 at DNA DSBs (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
      - WHSC1 binds DNA DSBs (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
      - WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Schizosaccharomyces pombe)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Schizosaccharomyces pombe)

Participants

members

Participates

as a component of

Inferred From

p-S140-H2AFX [nucleoplasm] (Homo sapiens)

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