Reactome | TFIIF [nucleoplasm]

TFIIF [nucleoplasm]

Stable Identifier

R-SSC-109631

Type

Complex

Species

Sus scrofa

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Metabolism of RNA (Sus scrofa)

- Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
  - Formation of pre-mRNPs (Sus scrofa)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
      - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - Internal Methylation of mRNA (Sus scrofa)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - mRNA Splicing (Sus scrofa)
    - mRNA Splicing - Major Pathway (Sus scrofa)
      - Formation of the Spliceosomal Bact complex (Sus scrofa)
        
        Spliceosomal B complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
        
        Spliceosomal Bact complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
      - Formation of the Spliceosomal C* complex (Sus scrofa)
        
        Spliceosomal C complex [nucleoplasm] (Sus scrofa)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
        
        Spliceosomal C* complex [nucleoplasm] (Sus scrofa)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
      - Formation of the Spliceosomal E complex (Sus scrofa)
        
        Spliceosomal E complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
      - Formation of the Spliceosomal P complex and exon ligation (Sus scrofa)
        
        Spliceosomal C* complex [nucleoplasm] (Sus scrofa)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
        
        Spliceosomal P complex [nucleoplasm] (Sus scrofa)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - mRNA Splicing - Minor Pathway (Sus scrofa)
      - ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Sus scrofa)
        
        ATAC C Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
        
        post exon ligation complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
      - ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Sus scrofa)
        
        ATAC C Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
      - Formation of AT-AC B Complex (Sus scrofa)
        
        ATAC A Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
        
        ATAC B Complex [nucleoplasm] (Sus scrofa)
        
        ATAC A Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
      - Formation of AT-AC C complex (Sus scrofa)
        
        ATAC B Complex [nucleoplasm] (Sus scrofa)
        
        ATAC A Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
        
        ATAC C Complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
- mRNA Capping (Sus scrofa)
  - Activation of GT (Sus scrofa)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - Capping complex formation (Sus scrofa)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - Capping complex (initial) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - Dissociation of transcript with 5'-GMP from GT (Sus scrofa)
    - Capping complex (GpppN..) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - Formation of the CE:GMP intermediate complex (Sus scrofa)
    - Capping complex (intermediate) [nucleoplasm] (Sus scrofa)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Sus scrofa)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - Capping complex (hydrolyzed) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Sus scrofa)
    - Capping complex (hydrolyzed) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - Capping complex (initial) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - Methylation of GMP-cap by RNA Methyltransferase (Sus scrofa)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - RNA Polymerase II CTD (phosphorylated) binds to CE (Sus scrofa)
    - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - Recognition and binding of the mRNA cap by the cap-binding complex (Sus scrofa)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Sus scrofa)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
  - Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Sus scrofa)
    - Capping complex (intermediate) [nucleoplasm] (Sus scrofa)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Sus scrofa)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
    - Capping complex (GpppN..) [nucleoplasm] (Sus scrofa)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Nuclear Receptors (Sus scrofa)
  - ESR-mediated signaling (Sus scrofa)
    - Estrogen-dependent gene expression (Sus scrofa)
      - ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Sus scrofa)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by FGFR (Sus scrofa)
    - Signaling by FGFR2 (Sus scrofa)
      - FGFR2 alternative splicing (Sus scrofa)
        
        PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Sus scrofa)
        
        FGFR2 IIIc-specific splicing complex [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Sus scrofa)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Sus scrofa)
        
        TFIIF [nucleoplasm] (Sus scrofa)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as an output of

Elongating transcript encounters a lesion in the template (Sus scrofa)

as a component of

Inferred From

TFIIF [nucleoplasm] (Homo sapiens)

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