Reactome | CHEK2 [nucleoplasm]

CHEK2 [nucleoplasm]

Stable Identifier

R-SSC-113824

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

CHEK2, A0A287A7U1

Locations in the PathwayBrowser

Expand all

Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G2/M Checkpoints (Sus scrofa)
    - G2/M DNA damage checkpoint (Sus scrofa)
      - CHEK2 is recruited to DNA DSBs (Sus scrofa)
        
        CHEK2 [nucleoplasm] (Sus scrofa)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Sus scrofa)
        
        CHEK2 [nucleoplasm] (Sus scrofa)
      - Phosphorylation and activation of CHEK2 by ATM (Sus scrofa)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Sus scrofa)
        
        CHEK2 [nucleoplasm] (Sus scrofa)

DNA Repair (Sus scrofa)

- DNA Double-Strand Break Repair (Sus scrofa)
  - DNA Double Strand Break Response (Sus scrofa)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Sus scrofa)
      - CHEK2 is recruited to DNA DSBs (Sus scrofa)
        
        CHEK2 [nucleoplasm] (Sus scrofa)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Sus scrofa)
        
        CHEK2 [nucleoplasm] (Sus scrofa)
      - Phosphorylation and activation of CHEK2 by ATM (Sus scrofa)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Sus scrofa)
        
        CHEK2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287A7U1

Gene Names

CHEK2

Reference Genes

ENSEMBL:ENSSSCG00000034864.3

Other Identifiers

100192447

GO:0000086

GO:0000278

GO:0000781

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005794

GO:0006281

GO:0006302

GO:0006351

GO:0006355

GO:0006468

GO:0006974

GO:0006978

GO:0007010

GO:0007059

GO:0008630

GO:0010332

GO:0012501

GO:0016301

GO:0016310

GO:0016605

GO:0016740

GO:0019901

GO:0023052

GO:0030163

GO:0031573

GO:0031625

GO:0036211

GO:0042176

GO:0042770

GO:0042771

GO:0042802

GO:0042803

GO:0043226

GO:0044773

GO:0045893

GO:0050821

GO:0070242

GO:0071480

GO:0090307

GO:0140014

GO:0140096

Ssc.4785.1.S1_at

Participates

as an input of

CHEK2 is recruited to DNA DSBs (Sus scrofa)

as a component of

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Sus scrofa)

Other forms of this molecule

phospho-CHEK2 [nucleoplasm]

Inferred From

CHEK2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000183765

Ensembl

ENSSSCG00000034864, ENSSSCT00000043678, ENSSSCP00000039835

VGNC

86638