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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
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CHUK [cytosol]
Stable Identifier
R-SSC-168104
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
F1S8V5
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Downstream signaling events of B Cell Receptor (BCR) (Sus scrofa)
Activation of NF-kappaB in B cells (Sus scrofa)
Activated IKK phosphorylates I-kappaB (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TCR signaling (Sus scrofa)
Downstream TCR signaling (Sus scrofa)
Activation of IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Interferon Signaling (Sus scrofa)
Antiviral mechanism by IFN-stimulated genes (Sus scrofa)
PKR-mediated signaling (Sus scrofa)
IKK complex is activated by PKR (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NEMO binds polyubiquitinated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Interleukin-17 signaling (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TNFR2 non-canonical NF-kB pathway (Sus scrofa)
NIK-->noncanonical NF-kB signaling (Sus scrofa)
Active NIK phosphorylates IKKA dimer (Sus scrofa)
IKKA dimer [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
Dectin-1 mediated noncanonical NF-kB signaling (Sus scrofa)
Active NIK phosphorylates IKKA dimer (Sus scrofa)
IKKA dimer [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated NF-kB activation (Sus scrofa)
Phosphorylation of IKK-beta by TAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of NEMO by TRAF6 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Toll-like Receptor Cascades (Sus scrofa)
Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
MyD88-independent TLR4 cascade (Sus scrofa)
TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
IKK complex recruitment mediated by RIP1 (Sus scrofa)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
MyD88 cascade initiated on plasma membrane (Sus scrofa)
IRAK1 recruits IKK complex (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
SLC15A4:TASL-dependent IRF5 activation (Sus scrofa)
Activated IKBKB phosphorylates IRF5 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
MyD88 dependent cascade initiated on endosome (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Sus scrofa)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
MAP kinase activation (Sus scrofa)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Sus scrofa)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Regulation of NF-kappa B signaling (Sus scrofa)
LRRC14 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
USP18 binds IKBKG within IKK complex (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
SLC15A4:TASL-dependent IRF5 activation (Sus scrofa)
Activated IKBKB phosphorylates IRF5 (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
TNF signaling (Sus scrofa)
Regulation of TNFR1 signaling (Sus scrofa)
GNB2L1 binds IKKA:IKKB:NEMO (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TNFR1-induced NF-kappa-B signaling pathway (Sus scrofa)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:F1S8V5
Reference Genes
ENSEMBL:ENSSSCG00000010548.6
Other Identifiers
100135662
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0007249
GO:0008384
GO:0008385
GO:0010628
GO:0016740
GO:0023052
GO:0032727
GO:0033209
GO:0034142
GO:0034614
GO:0036211
GO:0038061
GO:0042803
GO:0043123
GO:0043226
GO:0045893
GO:0045944
GO:0046982
GO:0050896
GO:0071276
GO:0071356
GO:0097110
GO:0098542
GO:0098586
GO:0140096
GO:1990459
Participates
as a component of
IKKA dimer [cytosol] (Sus scrofa)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:LRRC14 [cytosol] (Sus scrofa)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Sus scrofa)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Sus scrofa)
CHUK:IKBKB:IKBKG [cytosol] (Sus scrofa)
as an input of
LRRC14 binds IKBKB and CHUK (Sus scrofa)
NLRC5 binds IKBKB and CHUK (Sus scrofa)
CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)
as an output of
TRAF2,6 ubiquitinates NLRC5 (Sus scrofa)
Other forms of this molecule
phospho-p-Y187,Y198-CHUK [cytosol]
phospho-p-T23-CHUK [cytosol]
phospho-p-S176,S180-CHUK [cytosol]
Inferred From
CHUK [cytosol]
(Homo sapiens)
Cross References
Ensembl
ENSSSCG00000010548
,
ENSSSCT00000011540
,
ENSSSCP00000011239
VGNC
86688
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