Reactome | ADCY5 [plasma membrane]

ADCY5 [plasma membrane]

Stable Identifier

R-SSC-170684

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

I3L9P4

Locations in the PathwayBrowser

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Metabolism (Sus scrofa)

- Integration of energy metabolism (Sus scrofa)
  - Regulation of insulin secretion (Sus scrofa)
    - Adrenaline,noradrenaline inhibits insulin secretion (Sus scrofa)
      - G-beta:G-gamma inhibits Adenylate cyclase (Sus scrofa)
        
        Adenylate Cyclase V or VI [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase type V or VI: G-protein beta gamma Complex [plasma membrane] (Sus scrofa)
        
        Adenylate Cyclase V or VI [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)

Neuronal System (Sus scrofa)

- Transmission across Chemical Synapses (Sus scrofa)
  - Neurotransmitter receptors and postsynaptic signal transmission (Sus scrofa)
    - GABA receptor activation (Sus scrofa)
      - GABA B receptor activation (Sus scrofa)
        
        Activation of GABAB receptors (Sus scrofa)
        
        Adenylate cyclase inhibitory pathway (Sus scrofa)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        Dissociation of the Gi alpha:G olf complex (Sus scrofa)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - DAG and IP3 signaling (Sus scrofa)
    - CaM pathway (Sus scrofa)
      - Calmodulin induced events (Sus scrofa)
        
        PKA-mediated phosphorylation of CREB (Sus scrofa)
        
        PKA activation (Sus scrofa)
        
        Adenylate cyclase produces cAMP (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (i) signalling events (Sus scrofa)
      - Opioid Signalling (Sus scrofa)
        
        G-protein mediated events (Sus scrofa)
        
        Adenylate cyclase activating pathway (Sus scrofa)
        
        Adenylate cyclase converts ATP into cyclic AMP (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase inhibitory pathway (Sus scrofa)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        Dissociation of the Gi alpha:G olf complex (Sus scrofa)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        PLC beta mediated events (Sus scrofa)
        
        Ca-dependent events (Sus scrofa)
        
        CaM pathway (Sus scrofa)
        
        Calmodulin induced events (Sus scrofa)
        
        PKA-mediated phosphorylation of CREB (Sus scrofa)
        
        PKA activation (Sus scrofa)
        
        Adenylate cyclase produces cAMP (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
    - G alpha (z) signalling events (Sus scrofa)
      - G alpha (z) inhibits adenylate cyclase (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)
- Signaling by Hedgehog (Sus scrofa)
  - Hedgehog 'off' state (Sus scrofa)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Sus scrofa)
      - adenylate cyclases:Mg2+ [plasma membrane] (Sus scrofa)
        
        adenylate cyclases [plasma membrane] (Sus scrofa)
        
        ADCY5 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3L9P4

Reference Genes

ENSEMBL:ENSSSCG00000027952.4

Other Identifiers

100155970

GO:0001973

GO:0003824

GO:0004016

GO:0005886

GO:0005929

GO:0006171

GO:0007189

GO:0007191

GO:0007195

GO:0007204

GO:0007626

GO:0008179

GO:0009975

GO:0016020

GO:0016829

GO:0023052

GO:0043226

GO:0050877

GO:0050885

GO:0055086

GO:0061178

GO:0097110

GO:1901135

GO:1904322

Participates

as a candidate of

as a member of

Adenylate cyclase [plasma membrane] (Sus scrofa)

Inferred From

ADCY5 [plasma membrane] (Homo sapiens)

Cross References

Ensembl

ENSSSCP00000020757, ENSSSCT00000029344, ENSSSCG00000027952

VGNC

85109

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