Reactome | CD86 [plasma membrane]

CD86 [plasma membrane]

Stable Identifier

R-SSC-179784

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

CD86, K7GMU1

Locations in the PathwayBrowser

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Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - Negative regulation of the PI3K/AKT network (Sus scrofa)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
        
        PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activator:PI3K [plasma membrane] (Sus scrofa)
        
        CD28:PI3K [plasma membrane] (Sus scrofa)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Sus scrofa)
        
        CD86 [plasma membrane] (Sus scrofa)
    - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - Activator:PI3K [plasma membrane] (Sus scrofa)
        
        CD28:PI3K [plasma membrane] (Sus scrofa)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Sus scrofa)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Sus scrofa)
        
        CD86 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:K7GMU1

Gene Names

CD86

Reference Genes

BioGPS Gene:397441 CD86

ENSEMBL:ENSSSCG00000011877.5

ENSEMBL:ENSSSCG00005028668.1 CD86

Monarch:397441 CD86

NCBI Gene:397441 CD86

Reference Transcript

RefSeq:XM_005654040.2 CD86

Other Identifiers

397441

GO:0002376

GO:0005576

GO:0005615

GO:0005815

GO:0005856

GO:0005886

GO:0006955

GO:0007155

GO:0007166

GO:0009897

GO:0016020

GO:0023052

GO:0031295

GO:0034451

GO:0042102

GO:0042110

GO:0043226

GO:0048018

GO:0070062

GO:0071222

GO:0098772

Ssc.16160.1.S1_at

Participates

as an input of

CD28 homodimer binds B7-2 monomer (Sus scrofa)

as a component of

CD28:B7-2 [plasma membrane] (Sus scrofa)

as a member of

B7-1 homodimer/ B7-2 [plasma membrane] (Sus scrofa)

Inferred From

CD86 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005654097.1

OpenTargets

ENSG00000114013

Ensembl

ENSSSCP00000028828, ENSSSCT00000034076, ENSSSCG00000011877

VGNC

86435

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