Reactome | phospho-GAB1 [cytosol]

phospho-GAB1 [cytosol]

Stable Identifier

R-SSC-180344

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

p-5Y-GAB1, K7GMT0

Locations in the PathwayBrowser

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Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - RET signaling (Sus scrofa)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Sus scrofa)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Sus scrofa)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Sus scrofa)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Sus scrofa)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Sus scrofa)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - Negative regulation of the PI3K/AKT network (Sus scrofa)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
        
        PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activator:PI3K [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
    - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - Activator:PI3K [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by EGFR (Sus scrofa)
    - GAB1 signalosome (Sus scrofa)
      - Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - Dephosphorylation of Gab1 by SHP2 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - Dephosphorylation of PAG by SHP2 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - GAB1 phosphorylation by EGFR kinase (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - PI3K binds to EGF:EGFR:GRB2:GAB1 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)
        
        EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - Sustained activation of SRC kinase by SHP2 (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Sus scrofa)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Sus scrofa)
        
        GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
  - Signaling by MET (Sus scrofa)
    - MET activates PI3K/AKT signaling (Sus scrofa)
      - MET bound PI3K generates PIP3 (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - MET phosphorylates GAB1 (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
    - MET activates PTPN11 (Sus scrofa)
      - GAB1 binds PTPN11 (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
    - MET promotes cell motility (Sus scrofa)
      - MET activates RAP1 and RAC1 (Sus scrofa)
        
        CRK,CRKL recruits RAC1 GEF to activated MET (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        DOCK7 activates RAC1 (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        GAB1 recruits CRK,CRKL to MET (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        RAPGEF1 activates RAP1 (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        RAPGEF1 binds CRK,CRKL (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
    - MET receptor recycling (Sus scrofa)
      - GGA3 associates with activated MET receptor (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
      - RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Sus scrofa)
        
        phospho-GAB1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:K7GMT0

Gene Names

GAB1

Reference Genes

ENSEMBL:ENSSSCG00000009048.6

Other Identifiers

100511026

GO:0001525

GO:0005737

GO:0005911

GO:0007165

GO:0023052

GO:0035591

GO:0038084

GO:0045766

GO:0048856

GO:0048870

GO:0060090

GO:0090668

Ssc.11005.1.A1_at

Participates

as a member of

p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)

as a component of

Other forms of this molecule

phospho-GAB1 [cytosol]

GAB1 [cytosol]

Inferred From

p-5Y-GAB1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 627 (in Homo sapiens)

Coordinate

627

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 659 (in Homo sapiens)

Coordinate

659

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 447 (in Homo sapiens)

Coordinate

447

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 472 (in Homo sapiens)

Coordinate

472

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 589 (in Homo sapiens)

Coordinate

589

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000109458

Ensembl

ENSSSCG00000009048, ENSSSCP00000029177, ENSSSCT00000035764

VGNC

88294

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