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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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Docs
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RHOA [plasma membrane]
Stable Identifier
R-SSC-194510
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
plasma membrane
Synonyms
RHOA, I3LVS7
Locations in the PathwayBrowser
Expand all
Developmental Biology (Sus scrofa)
Nervous system development (Sus scrofa)
Axon guidance (Sus scrofa)
EPH-Ephrin signaling (Sus scrofa)
EPHA-mediated growth cone collapse (Sus scrofa)
NGEF exchanges GTP for GDP on RHOA (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
EPHB-mediated forward signaling (Sus scrofa)
RHOA:GTP binds ROCK, activating it (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Semaphorin interactions (Sus scrofa)
Sema4D in semaphorin signaling (Sus scrofa)
Sema4D induced cell migration and growth-cone collapse (Sus scrofa)
Activation of Rho by LARG and PDZ-RhoGEF (Sus scrofa)
RHOA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RhoA,B,C:GDP [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
ROCK activation by RHO (Sus scrofa)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Sema4D mediated inhibition of cell attachment and migration (Sus scrofa)
Inactivation of Rho-GTP by p190RhoGAP (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Signaling by ROBO receptors (Sus scrofa)
SLIT2:ROBO1 increases RHOA activity (Sus scrofa)
MYO9B inactivates RHOA (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
Neutrophil degranulation (Sus scrofa)
Exocytosis of ficolin-rich granule membrane proteins (Sus scrofa)
Ficolin-rich granule membrane proteins [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Exocytosis of secretory granule membrane proteins (Sus scrofa)
Secretory granule membrane proteins [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
p75 NTR receptor-mediated signalling (Sus scrofa)
p75NTR regulates axonogenesis (Sus scrofa)
Axonal growth inhibition (RHOA activation) (Sus scrofa)
RhoA is activated by nucleotide exchange and inhibits axonal growth (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
The p75NTR:NgR:MDGI binds RHOA-GDI (Sus scrofa)
RHOA:GDP:ARHGDIA [plasma membrane] (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Sus scrofa)
RHOA:GDP:ARHGDIA [plasma membrane] (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] (Sus scrofa)
RHOA:GDP:ARHGDIA [plasma membrane] (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Axonal growth stimulation (Sus scrofa)
NGF binding to p75NTR inactivates RHOA (Sus scrofa)
RHOA:GDP:ARHGDIA:NGFR [plasma membrane] (Sus scrofa)
RHOA:GDP:ARHGDIA [plasma membrane] (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GDP:ARHGDIA:NGFR:NGF [plasma membrane] (Sus scrofa)
RHOA:GDP:ARHGDIA:NGFR [plasma membrane] (Sus scrofa)
RHOA:GDP:ARHGDIA [plasma membrane] (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
p75NTR and RHOA-GDI interact (Sus scrofa)
RHOA:GDP:ARHGDIA [plasma membrane] (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GDP:ARHGDIA:NGFR [plasma membrane] (Sus scrofa)
RHOA:GDP:ARHGDIA [plasma membrane] (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (12/13) signalling events (Sus scrofa)
GEFs activate RhoA,B,C (Sus scrofa)
RHOA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RhoA,B,C:GDP [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
ROCK activation by RHO (Sus scrofa)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
p115-RhoGEF activation of RHOA (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
G-protein beta:gamma signalling (Sus scrofa)
G beta:gamma signalling through PI3Kgamma (Sus scrofa)
PIP3 binds to RhoA and activates it (Sus scrofa)
PIP3:RhoA [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Signaling by Non-Receptor Tyrosine Kinases (Sus scrofa)
Signaling by PTK6 (Sus scrofa)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Sus scrofa)
ARHGAP35 binds RHOA:GTP (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
ARHGAP35 stimulates RHOA GTPase activity (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ERBB2 (Sus scrofa)
ERBB2 Regulates Cell Motility (Sus scrofa)
MEMO1 binds RHOA:GTP:DIAPH1 (Sus scrofa)
RHOA:GTP:DIAPH1 [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Sus scrofa)
RHOA:GTP:DIAPH1 [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Signaling by NTRKs (Sus scrofa)
Signaling by NTRK1 (TRKA) (Sus scrofa)
PI3K/AKT activation (Sus scrofa)
PIP3 binds to RhoA and activates it (Sus scrofa)
PIP3:RhoA [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
ROCK1,ROCK2 are activated (Sus scrofa)
RHOA:GTP:ROCK1,ROCK2 [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase Effectors (Sus scrofa)
RHO GTPases Activate Formins (Sus scrofa)
DIAPH1 binds RHOA:GTP (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:DIAPH1 [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Sus scrofa)
RHOA:GTP:DIAPH1 [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:DIAPH1:EVL:Profilin:G-actin [plasma membrane] (Sus scrofa)
RHOA:GTP:DIAPH1 [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHO GTPases Activate ROCKs (Sus scrofa)
ROCK activation by RHO (Sus scrofa)
Activated ROCK:RhoA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA/B/C:GTP [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHO GTPases Activate Rhotekin and Rhophilins (Sus scrofa)
RHOA:GTP binds RHPN1 or RHPN2 (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:RHPN1,RHPN2 [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:RTKN binds LIN7B (Sus scrofa)
RHOA:GTP:RTKN [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:RTKN:LIN7B [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:RTKN binds TAX1BP3 (Sus scrofa)
RHOA:GTP:RTKN [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:RTKN:TAX1BP3 [plasma membrane] (Sus scrofa)
RHOA:GTP:RTKN [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHO GTPases activate CIT (Sus scrofa)
CIT-3 binds DLG4 (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:CIT-3 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHO GTPases activate PKNs (Sus scrofa)
PDPK1 phosphorylates PKN1,2,3 (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3 [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1:GTP [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHO GTPase cycle (Sus scrofa)
RHOA GTPase cycle (Sus scrofa)
GDIs block activation of RHOA (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA GAPs stimulate RHOA GTPase activity (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA GEFs activate RHOA (Sus scrofa)
RHOA:GDP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA binds effectors at the plasma membrane (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
RHOA:GTP translocates to the ER membrane (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
RHOA [plasma membrane] (Sus scrofa)
External Reference Information
External Reference
UniProt:I3LVS7
Gene Names
RHOA
Reference Genes
BioGPS Gene:396849 RHOA
ENSEMBL:ENSSSCG00000022080.4
ENSEMBL:ENSSSCG00005044357.1 RHOA
KEGG Gene (Sus scrofa):396849 RHOA
Monarch:396849 RHOA
NCBI Gene:396849 RHOA
Reference Transcript
RefSeq:NM_001244437.1 RHOA
Other Identifiers
396849
GO:0000166
GO:0000212
GO:0000278
GO:0000902
GO:0000910
GO:0001764
GO:0001822
GO:0001998
GO:0002363
GO:0002376
GO:0003012
GO:0003013
GO:0003014
GO:0003100
GO:0003189
GO:0003824
GO:0003924
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0005938
GO:0006091
GO:0006351
GO:0006355
GO:0006357
GO:0007010
GO:0007059
GO:0007155
GO:0007160
GO:0007163
GO:0007264
GO:0007266
GO:0007519
GO:0008092
GO:0009410
GO:0009898
GO:0010812
GO:0010975
GO:0012501
GO:0016020
GO:0016477
GO:0016787
GO:0017022
GO:0019003
GO:0019901
GO:0019904
GO:0021795
GO:0021861
GO:0022414
GO:0023052
GO:0030027
GO:0030036
GO:0030154
GO:0030307
GO:0030334
GO:0030424
GO:0030521
GO:0030838
GO:0030950
GO:0031098
GO:0031122
GO:0031410
GO:0031982
GO:0032154
GO:0032467
GO:0032587
GO:0032956
GO:0033144
GO:0033688
GO:0034329
GO:0034330
GO:0034446
GO:0035385
GO:0036089
GO:0038027
GO:0040016
GO:0040038
GO:0042060
GO:0042476
GO:0043123
GO:0043124
GO:0043149
GO:0043197
GO:0043226
GO:0043280
GO:0043296
GO:0043297
GO:0043366
GO:0043524
GO:0043525
GO:0043542
GO:0043931
GO:0044319
GO:0045198
GO:0045665
GO:0045666
GO:0045792
GO:0045987
GO:0046039
GO:0046638
GO:0048856
GO:0048870
GO:0050773
GO:0050886
GO:0050919
GO:0051022
GO:0051496
GO:0051653
GO:0051924
GO:0055086
GO:0060193
GO:0061024
GO:0061430
GO:0065003
GO:0070062
GO:0070507
GO:0071222
GO:0071345
GO:0071526
GO:0071803
GO:0071944
GO:0072687
GO:0090051
GO:0090307
GO:0090324
GO:0097049
GO:0097498
GO:0098794
GO:0098978
GO:0099159
GO:0140013
GO:0140014
GO:1901135
GO:1902766
GO:1903427
GO:1903673
GO:1904695
GO:1904996
GO:1905274
GO:1990869
GO:2000177
GO:2000406
GO:2000672
Ssc.7096.1.S1_at
Participates
as a member of
Ficolin-rich granule membrane proteins [plasma membrane] (Sus scrofa)
Secretory granule membrane proteins [plasma membrane] (Sus scrofa)
RHOA/B/C [plasma membrane] (Sus scrofa)
RHOA,RHOB,RHOC,RAC1 [plasma membrane] (Sus scrofa)
as a component of
RHOA:GDP [plasma membrane] (Sus scrofa)
PIP3:RhoA [plasma membrane] (Sus scrofa)
RHOA:GTP [plasma membrane] (Sus scrofa)
as an input of
PIP3 binds to RhoA and activates it (Sus scrofa)
Other forms of this molecule
RHOA [ficolin-1-rich granule membrane]
RHOA [secretory granule membrane]
RHOA [endoplasmic reticulum membrane]
RHOA [cytosol]
RHOA [cell junction]
Inferred From
RHOA [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001231366.1
OpenTargets
ENSG00000067560
Ensembl
ENSSSCT00000062870
,
ENSSSCP00000045785
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