Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
VAV2 [cytosol]
Stable Identifier
R-SSC-195012
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
VAV2, A0A287B8N4
Locations in the PathwayBrowser
Expand all
Developmental Biology (Sus scrofa)
Nervous system development (Sus scrofa)
Axon guidance (Sus scrofa)
EPH-Ephrin signaling (Sus scrofa)
EPH-ephrin mediated repulsion of cells (Sus scrofa)
SFKs phosphorylate VAV2,3 (Sus scrofa)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-EPHs bind VAV2,3 (Sus scrofa)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
GPVI-mediated activation cascade (Sus scrofa)
VAV1 is a GEF for Rho/Rac family GTPases (Sus scrofa)
PIP3:VAV1,2,3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
VAV family:PIP2 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-SLP-76 binds VAV (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-SLP-76:VAV [cytosol] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
DAP12 interactions (Sus scrofa)
DAP12 signaling (Sus scrofa)
Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Phosphorylation of BTK by p-SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-SYK/p-BTK [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Release of p-PLCG1 (Sus scrofa)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated Ca+2 mobilization (Sus scrofa)
Autophosphorylation of BTK/ITK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Hydrolysis of PIP2 by PLCG (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Phosphorylation of TEC kinases by p-SYK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
FCERI mediated MAPK activation (Sus scrofa)
Phosphorylation and activation of VAV (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Recruitment of VAV to p-SLP-76 (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
Phosphorylation of VAV (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Recruitment of VAV1 to p-6Y-SYK (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Death Receptor Signaling (Sus scrofa)
p75 NTR receptor-mediated signalling (Sus scrofa)
Cell death signalling via NRAGE, NRIF and NADE (Sus scrofa)
NRAGE signals death through JNK (Sus scrofa)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Sus scrofa)
GEFs [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (12/13) signalling events (Sus scrofa)
GEFs activate RhoA,B,C (Sus scrofa)
GEFs [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
Src kinases phosphorylate VAV (Sus scrofa)
PIP3:VAV1,2,3 [plasma membrane] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase cycle (Sus scrofa)
CDC42 GTPase cycle (Sus scrofa)
CDC42 GEFs activate CDC42 (Sus scrofa)
CDC42 GEFs [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
RAC1 GTPase cycle (Sus scrofa)
RAC1 GEFs activate RAC1 (Sus scrofa)
RAC1 GEFs [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
RAC2 GTPase cycle (Sus scrofa)
RAC2 GEFs activate RAC2 (Sus scrofa)
RAC2 GEFs [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
RAC3 GTPase cycle (Sus scrofa)
RAC3 GEFs activate RAC3 (Sus scrofa)
RAC3 GEFs [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
RHOA GTPase cycle (Sus scrofa)
RHOA GEFs activate RHOA (Sus scrofa)
RHOA GEFs [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
RHOB GTPase cycle (Sus scrofa)
RHOB GEFs activate RHOB (Sus scrofa)
RHOB GEFs [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
RHOC GTPase cycle (Sus scrofa)
RHOC GEFs activate RHOC (Sus scrofa)
RHOC GEFs [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
RHOG GTPase cycle (Sus scrofa)
RHOG GEFs activate RHOG (Sus scrofa)
RHOG GEFs [cytosol] (Sus scrofa)
VAV2 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287B8N4
Gene Names
VAV2
Reference Genes
ENSEMBL:ENSSSCG00000005743.5
UCSC:A0A287B8N4 VAV2
Other Identifiers
100151931
GO:0001784
GO:0005085
GO:0005154
GO:0005737
GO:0005886
GO:0007165
GO:0007264
GO:0008361
GO:0016477
GO:0023052
GO:0030031
GO:0030032
GO:0035556
GO:0046872
GO:0048870
GO:0051897
GO:0098772
Ssc.24162.1.S1_at
Participates
as a member of
RHOA GEFs [cytosol] (Sus scrofa)
RHOC GEFs [cytosol] (Sus scrofa)
RAC2 GEFs [cytosol] (Sus scrofa)
RAC1 GEFs [cytosol] (Sus scrofa)
RHOB GEFs [cytosol] (Sus scrofa)
RAC3 GEFs [cytosol] (Sus scrofa)
GEFs [cytosol] (Sus scrofa)
VAV1,2,3 [cytosol] (Sus scrofa)
as a candidate of
CDC42 GEFs [cytosol] (Sus scrofa)
RHOG GEFs [cytosol] (Sus scrofa)
as an input of
p-EPHs bind VAV2,3 (Sus scrofa)
Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)
as a component of
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
Other forms of this molecule
phospho-VAV2 [cytosol]
Inferred From
VAV2,VAV3 [cytosol]
(Homo sapiens)
VAV2 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSSSCG00000005743
,
ENSSSCT00000044450
,
ENSSSCP00000052682
VGNC
94808
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text