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BTK [cytosol]
Stable Identifier
R-SSC-197948
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
I3LN58
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)
BTK binds BTK inhibitors (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
BTK:PIP3 [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
BTK:BTK inhibitors [plasma membrane] (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
BTK:PIP3 [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
BTK:PIP3 [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
Innate Immune System (Sus scrofa)
DAP12 interactions (Sus scrofa)
DAP12 signaling (Sus scrofa)
Activation of RAC1 by VAV2/3 (Sus scrofa)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
Phosphorylation of BTK by p-SYK (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)
BTK [cytosol] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated Ca+2 mobilization (Sus scrofa)
Phosphorylation of TEC kinases by p-SYK (Sus scrofa)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
TEC,BTK,ITK,(TXK) [cytosol] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (12/13) signalling events (Sus scrofa)
BTK in G alpha (12)-BTK complex is activated (Sus scrofa)
G alpha (12):BTK [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
G alpha (12) binds BTK (Sus scrofa)
BTK [cytosol] (Sus scrofa)
G alpha (12):BTK [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Sus scrofa)
BTK [cytosol] (Sus scrofa)
G alpha (12):BTK [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
G alpha (q) signalling events (Sus scrofa)
Active Gq binds BTK (Sus scrofa)
Active Gq:BTK [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
BTK in active Gq-BTK complex is activated (Sus scrofa)
Active Gq:BTK [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
Gq-BTK complex dissociates to Active BTK and Gq (Sus scrofa)
Active Gq:BTK [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
G-protein beta:gamma signalling (Sus scrofa)
G beta:gamma signalling through BTK (Sus scrofa)
BTK in PIP3:BTK:G beta-gamma complex is activated (Sus scrofa)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
G beta-gamma complex and PIP3 recruit BTK to membrane (Sus scrofa)
BTK [cytosol] (Sus scrofa)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Sus scrofa)
BTK [cytosol] (Sus scrofa)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
BTK [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:I3LN58
Reference Genes
ENSEMBL:ENSSSCG00000026742.4
UCSC:I3LN58
Other Identifiers
100627308
GO:0000166
GO:0001818
GO:0002250
GO:0002344
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005524
GO:0005547
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0008289
GO:0016004
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030889
GO:0031410
GO:0035556
GO:0036211
GO:0042802
GO:0043226
GO:0043274
GO:0045121
GO:0046872
GO:0048469
GO:0048856
GO:0050853
GO:0065003
GO:0098761
GO:0098772
GO:0140096
GO:1900227
Ssc.15419.1.S1_at
Participates
as an output of
Gq-BTK complex dissociates to Active BTK and Gq (Sus scrofa)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Sus scrofa)
PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Sus scrofa)
as an input of
Active Gq binds BTK (Sus scrofa)
G alpha (12) binds BTK (Sus scrofa)
G beta-gamma complex and PIP3 recruit BTK to membrane (Sus scrofa)
Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)
as a component of
Active Gq:BTK [plasma membrane] (Sus scrofa)
G alpha (12):BTK [plasma membrane] (Sus scrofa)
PIP3:BTK:G-protein beta-gamma complex [plasma membrane] (Sus scrofa)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
BTK:PIP3 [plasma membrane] (Sus scrofa)
as a member of
TEC,BTK,ITK,(TXK) [cytosol] (Sus scrofa)
Other forms of this molecule
phospho-p-Y223,Y551-BTK [cytosol]
phospho-p-Y551-BTK [cytosol]
phospho-p-Y223,Y551-BTK [plasma membrane]
Inferred From
Active BTK [cytosol]
(Homo sapiens)
BTK [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSSSCP00000025530
,
ENSSSCG00000026742
,
ENSSSCT00000025835
VGNC
85914
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