Reactome | PI3K alpha [cytosol]

Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - RET signaling (Sus scrofa)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)

Hemostasis (Sus scrofa)

- Platelet activation, signaling and aggregation (Sus scrofa)
  - GPVI-mediated activation cascade (Sus scrofa)
    - PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)
      - PI3K alpha, beta, gamma [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Costimulation by the CD28 family (Sus scrofa)
    - CD28 co-stimulation (Sus scrofa)
      - CD28 dependent PI3K/Akt signaling (Sus scrofa)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        CD28:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PI3K binds CD28 (Sus scrofa)
        
        CD28:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
    - PI3K binds ICOS (Sus scrofa)
      - ICOS:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
      - PI3K alpha [cytosol] (Sus scrofa)
- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-2 family signaling (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
      - 14-3-3 zeta binding allows recruitment of PI3K (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
      - Regulation of signaling by CBL (Sus scrofa)
        
        CBL ubiquitinates PI3K (Sus scrofa)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - Negative regulation of the PI3K/AKT network (Sus scrofa)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
        
        PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activator:PI3K [plasma membrane] (Sus scrofa)
        
        CD28:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        ICOS:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
    - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - Activator:PI3K [plasma membrane] (Sus scrofa)
        
        CD28:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        ICOS:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
    - RAC1,RAC2,RHOG activate PI3K (Sus scrofa)
      - PI3K alpha [cytosol] (Sus scrofa)
      - RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (q) signalling events (Sus scrofa)
      - G alpha (q) inhibits PI3K alpha (Sus scrofa)
        
        G-protein alpha (q/11):PI3K alpha [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
- Signaling by Nuclear Receptors (Sus scrofa)
  - ESR-mediated signaling (Sus scrofa)
    - Extra-nuclear estrogen signaling (Sus scrofa)
      - PI3K binds membrane-associated estrogen receptors (Sus scrofa)
        
        ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by SCF-KIT (Sus scrofa)
    - Direct recruitment of PI3K to p-KIT (Sus scrofa)
      - PI3K alpha [cytosol] (Sus scrofa)
      - PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)
      - PI3K alpha [cytosol] (Sus scrofa)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
    - Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
  - Signaling by Rho GTPases (Sus scrofa)
    - RHO GTPase cycle (Sus scrofa)
      - RAC1 GTPase cycle (Sus scrofa)
        
        RAC1 binds effectors at the plasma membrane (Sus scrofa)
        
        RAC1 effectors [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Sus scrofa)
        
        RAC1 effectors [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
      - RAC2 GTPase cycle (Sus scrofa)
        
        RAC2 binds effectors at the plasma membrane (Sus scrofa)
        
        RAC2 plasma membrane effectors [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)
        
        RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Sus scrofa)
        
        RAC2 plasma membrane effectors [cytosol] (Sus scrofa)
        
        PI3K alpha [cytosol] (Sus scrofa)