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PTN [extracellular region]
Stable Identifier
R-SSC-201500
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
extracellular region
Synonyms
PTN, P79281
Locations in the PathwayBrowser
Expand all
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
ALK autophosphorylation (Sus scrofa)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Sus scrofa)
ligand-bound ALK dimer [plasma membrane] (Sus scrofa)
PTN:ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
ligand-bound ALK dimer [plasma membrane] (Sus scrofa)
PTN:ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK binds JAK3 (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK:JAK3 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK binds PLCG1 (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK:PLCG1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK binds SHC1 (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK:SHC1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK dimer binds IRS1 (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK:IRS1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK phosphorylates IRS1 (Sus scrofa)
Active ALK:IRS1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK:pY-IRS1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK phosphorylates JAK3 (Sus scrofa)
Active ALK:JAK3 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK:p-Y980 JAK3 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK phosphorylates PLCG1 (Sus scrofa)
Active ALK:PLCG1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK:p-4Y PLCG1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK phosphorylates SHC1 (Sus scrofa)
Active ALK:SHC1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK:p-3Y SHC1 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK recruits PI3K (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK:PI3K [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Liganded-ALK dimer binds type I ALK-binding TKIs (Sus scrofa)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Sus scrofa)
ligand-bound ALK dimer [plasma membrane] (Sus scrofa)
PTN:ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
ligand-bound ALK dimer [plasma membrane] (Sus scrofa)
PTN:ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
MDK and PTN in ALK signaling (Sus scrofa)
(PTN,MDK):PTPRZ oligomerizes (Sus scrofa)
(PTN,MDK):PTPRZ [plasma membrane] (Sus scrofa)
PTN,MDK [extracellular region] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Sus scrofa)
(PTN,MDK):PTPRZ [plasma membrane] (Sus scrofa)
PTN,MDK [extracellular region] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
ALK binds ligand pleiotrophin (PTN) (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
PTN:ALK [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
PTN and MDK bind to PTPRZ (Sus scrofa)
(PTN,MDK):PTPRZ [plasma membrane] (Sus scrofa)
PTN,MDK [extracellular region] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
PTN,MDK [extracellular region] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
PTPRZ dephosphorylates ligand-bound ALK dimers (Sus scrofa)
(PTN,MDK):ALK dimer [plasma membrane] (Sus scrofa)
PTN:ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Sus scrofa)
(PTN,MDK):PTPRZ [plasma membrane] (Sus scrofa)
PTN,MDK [extracellular region] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
(PTN,MDK):p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)
Active ALK:PI3K [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
PTPN6 dephosphorylates JAK3 (Sus scrofa)
Active ALK:JAK3 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
Active ALK:p-Y980 JAK3 [plasma membrane] (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
STAT3 is phosphorylated downstream of active ALK (Sus scrofa)
Active ALK dimer [plasma membrane] (Sus scrofa)
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN [extracellular region] (Sus scrofa)
External Reference Information
External Reference
UniProt:P79281
Gene Names
PTN
Reference Genes
BioGPS Gene:397609 PTN
ENSEMBL:ENSSSCG00000016522.6 PTN
ENSEMBL:ENSSSCG00005019128.1 PTN
ENSEMBL:ENSSSCG00015076742.1 PTN
ENSEMBL:ENSSSCG00025009799.1 PTN
ENSEMBL:ENSSSCG00035014369.1 PTN
ENSEMBL:ENSSSCG00045023122.1 PTN
ENSEMBL:ENSSSCG00055028221.1 PTN
ENSEMBL:ENSSSCG00065004603.1 PTN
ENSEMBL:ENSSSCG00070025592.1
KEGG Gene (Sus scrofa):397609 PTN
Monarch:397609 PTN
NCBI Gene:397609 PTN
Reference Transcript
RefSeq:NM_214336.1 PTN
RefSeq:XM_013985586.1 PTN
Other Identifiers
397609
GO:0001503
GO:0002232
GO:0002376
GO:0002690
GO:0004864
GO:0005178
GO:0005576
GO:0005615
GO:0005783
GO:0006954
GO:0007229
GO:0007406
GO:0007612
GO:0007613
GO:0008083
GO:0008201
GO:0008284
GO:0010996
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0030282
GO:0030501
GO:0031641
GO:0032991
GO:0035374
GO:0042246
GO:0043113
GO:0043226
GO:0043932
GO:0044849
GO:0045597
GO:0046697
GO:0048018
GO:0048167
GO:0048477
GO:0048714
GO:0048856
GO:0048870
GO:0050804
GO:0050877
GO:0098685
GO:0098772
GO:0140059
GO:0140677
GO:1900006
GO:1900272
GO:1903706
GO:2000036
GO:2000347
GO:2000738
Ssc.12975.1.S1_at
Participates
as a member of
PTN,MDK [extracellular region] (Sus scrofa)
as a component of
PTN:p-7Y ALK dimer [plasma membrane] (Sus scrofa)
PTN:ALK [plasma membrane] (Sus scrofa)
PTN:ALK dimer [plasma membrane] (Sus scrofa)
as an input of
ALK binds ligand pleiotrophin (PTN) (Sus scrofa)
Inferred From
PTN [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_013841040.1
,
NP_999501.1
OpenTargets
ENSG00000105894
Ensembl
ENSSSCT00000017990
,
ENSSSCP00000017506
,
ENSSSCG00000016522
VGNC
91965
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