Reactome | ACTB [cytosol]

ACTB [cytosol]

Stable Identifier

R-SSC-201861

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

ACTB(1-375), Q6QAQ1

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Sus scrofa)

- Cell junction organization (Sus scrofa)
  - Cell-extracellular matrix interactions (Sus scrofa)
    - MigFilin associates with Filamin and F-actin (Sus scrofa)
      - F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
      - Migfilin:Filamin A:F-actin [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)

Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - EPH-Ephrin signaling (Sus scrofa)
      - EPHB-mediated forward signaling (Sus scrofa)
        
        N-WASP binds ARP2/3 and G-actin (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)

Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
      - Branching and elongation of mother and daughter filaments (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Sus scrofa)
        
        Actin:ADP [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Mother filament:branching complex:daughter filament [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
      - Detachment of WASP/WAVE (Sus scrofa)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Sus scrofa)
        
        Actin:ADP [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Mother filament:branching complex [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
      - Extension of pseudopodia by myosin-X in a PI3K dependent manner (Sus scrofa)
        
        Actin filament bound Myosin-X [plasma membrane] (Sus scrofa)
        
        Mother filament:branching complex:daughter filament [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Mother filament:branching complex:daughter filament [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
      - Role of myosins in phagosome formation (Sus scrofa)
        
        Mother filament:branching complex:daughter filament [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)
        
        Myosin-Actin filaments [cytosol] (Sus scrofa)
        
        Mother filament:branching complex:daughter filament [cytosol] (Sus scrofa)
        
        F-actin [cytosol] (Sus scrofa)
        
        G-actin [cytosol] (Sus scrofa)
        
        actin [cytosol] (Sus scrofa)
        
        ACTB [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q6QAQ1

Gene Names

ACTB

Reference Genes

BioGPS Gene:414396 ACTB

ENSEMBL:ENSSSCG00000007585.5 ACTB

ENSEMBL:ENSSSCG00005020690.1 ACTB

ENSEMBL:ENSSSCG00030003451.1 ACTB

ENSEMBL:ENSSSCG00035038792.1 ACTB

ENSEMBL:ENSSSCG00040049462.1 ACTB

ENSEMBL:ENSSSCG00045027458.1

ENSEMBL:ENSSSCG00050065025.1 ACTB

ENSEMBL:ENSSSCG00055012597.1 ACTB

ENSEMBL:ENSSSCG00060019124.1 ACTB

ENSEMBL:ENSSSCG00065037921.1 ACTB

ENSEMBL:ENSSSCG00070011353.1 ACTB

KEGG Gene (Sus scrofa):414396 ACTB

Monarch:414396 ACTB

NCBI Gene:414396 ACTB

Reference Transcript

RefSeq:XM_003124280.4 ACTB

Other Identifiers

414396

GO:0000786

GO:0001738

GO:0005198

GO:0005634

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005903

GO:0005911

GO:0005912

GO:0006281

GO:0006310

GO:0007010

GO:0007163

GO:0008092

GO:0015629

GO:0016192

GO:0019894

GO:0019901

GO:0030027

GO:0030863

GO:0030957

GO:0032991

GO:0034330

GO:0034333

GO:0035267

GO:0036464

GO:0042802

GO:0043226

GO:0043296

GO:0044305

GO:0045176

GO:0048856

GO:0048870

GO:0050998

GO:0051621

GO:0051726

GO:0070160

GO:0071896

GO:0072659

GO:0072749

GO:0098685

GO:0098871

GO:0098973

GO:0098974

GO:0098978

GO:0150111

GO:1900242

GO:1903076

GO:1905168

GO:1990904

Participates

as a candidate of

RHOF effectors [cytosol] (Sus scrofa)

as a member of

actin [cytosol] (Sus scrofa)

Other forms of this molecule

ACTB [nucleoplasm]

ACTB [lysosomal membrane]

ACTB [plasma membrane]

Inferred From

ACTB(1-375) [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_003124328.1

OpenTargets

ENSG00000075624

Ensembl

ENSSSCT00000042531, ENSSSCP00000035521, ENSSSCG00000007585

VGNC

96915

PDB

6ZNN, 6ZNO, 6ZNL, 6ZNM, 8IAI, 8IAH, 6F3A, 7Z8M, 5ADX, 5AFU, 7Z8F, 6F38, 6ZO4, 6F1T, 8IB2

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