Reactome | DUSP4 [nucleoplasm]

DUSP4 [nucleoplasm]

Stable Identifier

R-SSC-203794

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

DUSP4, F1RX60

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-17 signaling (Sus scrofa)
      - MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        ERK-specific DUSP [nucleoplasm] (Sus scrofa)
        
        DUSP4 [nucleoplasm] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        ERK-specific DUSP [nucleoplasm] (Sus scrofa)
        
        DUSP4 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
      - Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        ERK-specific DUSP [nucleoplasm] (Sus scrofa)
        
        DUSP4 [nucleoplasm] (Sus scrofa)
      - Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        ERK-specific DUSP [nucleoplasm] (Sus scrofa)
        
        DUSP4 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
      - MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        ERK-specific DUSP [nucleoplasm] (Sus scrofa)
        
        DUSP4 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        ERK-specific DUSP [nucleoplasm] (Sus scrofa)
        
        DUSP4 [nucleoplasm] (Sus scrofa)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        ERK-specific DUSP [nucleoplasm] (Sus scrofa)
        
        DUSP4 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        ERK-specific DUSP [nucleoplasm] (Sus scrofa)
        
        DUSP4 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        ERK-specific DUSP [nucleoplasm] (Sus scrofa)
        
        DUSP4 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        ERK-specific DUSP [nucleoplasm] (Sus scrofa)
        
        DUSP4 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RX60

Gene Names

DUSP4

Reference Genes

BioGPS Gene:100514374 DUSP4

ENSEMBL:ENSSSCG00000015850.5

KEGG Gene (Sus scrofa):100514374 DUSP4

Monarch:100514374 DUSP4

NCBI Gene:100514374 DUSP4

Reference Transcript

RefSeq:XM_003133392.3 DUSP4

Other Identifiers

100514374

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005634

GO:0005654

GO:0006470

GO:0008138

GO:0008330

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0017018

GO:0023052

GO:0036211

GO:0043226

GO:0070373

GO:0140096

GO:1990439

Ssc.2112.1.S1_at

Participates

as a candidate of

nuclear MAPK DUSPs [nucleoplasm] (Sus scrofa)

as a member of

ERK-specific DUSP [nucleoplasm] (Sus scrofa)

Inferred From

DUSP4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_003133440.1

OpenTargets

ENSG00000120875

Ensembl

ENSSSCP00000016796, ENSSSCG00000015850, ENSSSCT00000017258

VGNC

96248

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