Reactome | HDAC2 [nucleoplasm]

HDAC2 [nucleoplasm]

Stable Identifier

R-SSC-205135

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

HDAC2, F1RZK8

Locations in the PathwayBrowser

Expand all

Chromatin organization (Sus scrofa)

- Chromatin modifying enzymes (Sus scrofa)
  - HDACs deacetylate histones (Sus scrofa)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - HDAC1:2-containing complex deacetylate histones (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase I Transcription (Sus scrofa)
  - RNA Polymerase I Promoter Clearance (Sus scrofa)
    - RNA Polymerase I Transcription Initiation (Sus scrofa)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Notch-HLH transcription pathway (Sus scrofa)
      - Formation of CSL NCOR corepressor complex (Sus scrofa)
        
        HDAC [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        RBPJ:NCOR corepressor complex [nucleoplasm] (Sus scrofa)
        
        HDAC [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - Transcriptional Regulation by MECP2 (Sus scrofa)
      - Regulation of MECP2 expression and activity (Sus scrofa)
        
        MECP2 binds the SIN3A co-repressor complex (Sus scrofa)
        
        MECP2:SIN3A:HDAC1,HDAC2 [nucleoplasm] (Sus scrofa)
        
        MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        MECP2:SIN3A:HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - Regulation of TP53 Activity (Sus scrofa)
        
        Regulation of TP53 Activity through Acetylation (Sus scrofa)
        
        MTA2-NuRD complex deacetylates TP53 (Sus scrofa)
        
        MTA2-NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Hemostasis (Sus scrofa)

- Factors involved in megakaryocyte development and platelet production (Sus scrofa)
  - REST recruits the BHC complex (Sus scrofa)
    - BHC complex [nucleoplasm] (Sus scrofa)
      - HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - BHC complex:REST:REST DNA binding sites [nucleoplasm] (Sus scrofa)
      - BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RZK8

Gene Names

HDAC2

Reference Genes

BioGPS Gene:100156170 HDAC2

ENSEMBL:ENSSSCG00000004432

KEGG Gene (Sus scrofa):100156170 HDAC2

Monarch:100156170 HDAC2

NCBI Gene:100156170 HDAC2

Reference Transcript

RefSeq:XM_001925318.5 HDAC2

Other Identifiers

100156170

GO:0000122

GO:0000228

GO:0001103

GO:0003674

GO:0003677

GO:0004407

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006464

GO:0007165

GO:0008134

GO:0008150

GO:0008283

GO:0008284

GO:0009058

GO:0016575

GO:0016580

GO:0016581

GO:0016810

GO:0019899

GO:0032991

GO:0033558

GO:0034641

GO:0035098

GO:0042826

GO:0043226

GO:0043433

GO:0043565

GO:0045862

GO:0045892

GO:0045944

GO:0051059

GO:0051276

GO:0070829

GO:2000273

Ssc.3040.1.S1_at

Participates

as a component of

as a candidate of

HDAC [nucleoplasm] (Sus scrofa)

Inferred From

HDAC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_001925353.2

OpenTargets

ENSG00000196591

Ensembl

ENSSSCP00000004781, ENSSSCT00000004897, ENSSSCG00000004432

VGNC

88813

Cite Us!