Reactome | HDAC2 [nucleoplasm]

HDAC2 [nucleoplasm]

Stable Identifier

R-SSC-205135

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

HDAC2, F1RZK8

Locations in the PathwayBrowser

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Cell-Cell communication (Sus scrofa)

- Cell junction organization (Sus scrofa)
  - Cell-cell junction organization (Sus scrofa)
    - Adherens junctions interactions (Sus scrofa)
      - Regulation of Homotypic Cell-Cell Adhesion (Sus scrofa)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Sus scrofa)
        
        Regulation of CDH1 Expression and Function (Sus scrofa)
        
        Regulation of CDH1 Gene Transcription (Sus scrofa)
        
        Negative Regulation of CDH1 Gene Transcription (Sus scrofa)
        
        ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter (Sus scrofa)
        
        HDAC1,(HDAC2) dimers [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC1,(HDAC2):TLE1:ZEB1:CDH1 gene [nucleoplasm] (Sus scrofa)
        
        HDAC1,(HDAC2) dimers [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Chromatin organization (Sus scrofa)

- Chromatin modifying enzymes (Sus scrofa)
  - HDACs deacetylate histones (Sus scrofa)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - HDAC1:2-containing complex deacetylate histones (Sus scrofa)
      - HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Sus scrofa)
        
        HDAC1:2-containing complex [nucleoplasm] (Sus scrofa)
        
        BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        CoREST complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        Sin3A complex [nucleoplasm] (Sus scrofa)
        
        Sin3a core complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase I Transcription (Sus scrofa)
  - RNA Polymerase I Promoter Clearance (Sus scrofa)
    - RNA Polymerase I Transcription Initiation (Sus scrofa)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Sus scrofa)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Notch-HLH transcription pathway (Sus scrofa)
      - Formation of CSL NCOR corepressor complex (Sus scrofa)
        
        HDAC [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        RBPJ:NCOR corepressor complex [nucleoplasm] (Sus scrofa)
        
        HDAC [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - Transcriptional Regulation by MECP2 (Sus scrofa)
      - Regulation of MECP2 expression and activity (Sus scrofa)
        
        MECP2 binds the SIN3A co-repressor complex (Sus scrofa)
        
        MECP2:SIN3A:HDAC1,HDAC2 [nucleoplasm] (Sus scrofa)
        
        MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        MECP2:SIN3A:HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        SIN3A:HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 homodimer [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - Regulation of TP53 Activity (Sus scrofa)
        
        Regulation of TP53 Activity through Acetylation (Sus scrofa)
        
        MTA2-NuRD complex deacetylates TP53 (Sus scrofa)
        
        MTA2-NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Hemostasis (Sus scrofa)

- Factors involved in megakaryocyte development and platelet production (Sus scrofa)
  - REST recruits the BHC complex (Sus scrofa)
    - BHC complex [nucleoplasm] (Sus scrofa)
      - HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
    - BHC complex:REST:REST DNA binding sites [nucleoplasm] (Sus scrofa)
      - BHC complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - SUMOylation (Sus scrofa)
    - SUMO E3 ligases SUMOylate target proteins (Sus scrofa)
      - SUMOylation of chromatin organization proteins (Sus scrofa)
        
        SUMOylation of HDAC2 with SUMO1 (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - PTEN Regulation (Sus scrofa)
      - Regulation of PTEN gene transcription (Sus scrofa)
        
        SALL4 recruits NuRD to PTEN gene (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Sus scrofa)
        
        SALL4:NuRD [nucleoplasm] (Sus scrofa)
        
        NuRD complex [nucleoplasm] (Sus scrofa)
        
        HDAC1:HDAC2 [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by ALK (Sus scrofa)
    - STAT3 nuclear events downstream of ALK signaling (Sus scrofa)
      - HDACs deacetylate p-STAT3 dimers (Sus scrofa)
        
        Histone deacetylase [nucleoplasm] (Sus scrofa)
        
        HDAC2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1RZK8

Gene Names

HDAC2

Reference Genes

BioGPS Gene:100156170 HDAC2

ENSEMBL:ENSSSCG00000004432.5

KEGG:ssc:100156170 HDAC2

Monarch:100156170 HDAC2

NCBI Gene:100156170 HDAC2

UCSC:F1RZK8 HDAC2

Reference Transcript

RefSeq:XM_001925318.6 HDAC2

Other Identifiers

100156170

GO:0000118

GO:0000122

GO:0000781

GO:0003824

GO:0004407

GO:0005634

GO:0005654

GO:0005737

GO:0006325

GO:0006338

GO:0006355

GO:0008284

GO:0010944

GO:0016020

GO:0016581

GO:0016787

GO:0019899

GO:0031078

GO:0031507

GO:0032129

GO:0032991

GO:0033558

GO:0034739

GO:0035098

GO:0042393

GO:0042826

GO:0043226

GO:0045862

GO:0045944

GO:0046872

GO:0051059

GO:0061629

GO:0070822

GO:0140096

GO:0140937

GO:0160008

GO:0160009

GO:0160010

GO:0160216

GO:0180032

GO:0180033

GO:1990162

Ssc.3040.1.S1_at

Participates

as an input of

SUMOylation of HDAC2 with SUMO1 (Sus scrofa)

as a component of

as a member of

Histone deacetylase [nucleoplasm] (Sus scrofa)

as a candidate of

HDAC [nucleoplasm] (Sus scrofa)

Other forms of this molecule

HDAC2 [nucleoplasm]

Inferred From

HDAC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_001925353.2

ENSEMBL

ENSSSCT00000004897, ENSSSCG00000004432, ENSSSCP00000004781

VGNC

88813

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