Reactome | FBXO32 [cytosol]

FBXO32 [cytosol]

Stable Identifier

R-SSC-264453

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

FBXO32, Q1A730

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Class I MHC mediated antigen processing & presentation (Sus scrofa)
    - Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
      - Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
      - Polyubiquitination of substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
      - Release of E3 from polyubiquitinated substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
      - Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Neddylation (Sus scrofa)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Sus scrofa)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Sus scrofa)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Sus scrofa)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Sus scrofa)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        SCF E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        F-box protein [cytosol] (Sus scrofa)
        
        FBXO32 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q1A730

Gene Names

FBXO32

Reference Genes

BioGPS Gene:733657 FBXO32

ENSEMBL:ENSSSCG00000005981.5 FBXO32

ENSEMBL:ENSSSCG00005030776.1 FBXO32

ENSEMBL:ENSSSCG00015081012.1 FBXO32

ENSEMBL:ENSSSCG00025039530.1 FBXO32

ENSEMBL:ENSSSCG00030055185.1 FBXO32

ENSEMBL:ENSSSCG00035042848.1 FBXO32

ENSEMBL:ENSSSCG00040059594.1 FBXO32

ENSEMBL:ENSSSCG00045017934.1 FBXO32

ENSEMBL:ENSSSCG00050012882.1

ENSEMBL:ENSSSCG00055012753.1 FBXO32

ENSEMBL:ENSSSCG00060015331.1 FBXO32

ENSEMBL:ENSSSCG00065068772.1 FBXO32

ENSEMBL:ENSSSCG00070005842.1 FBXO32

KEGG Gene (Sus scrofa):733657 FBXO32

Monarch:733657 FBXO32

NCBI Gene:733657 FBXO32

Reference Transcript

RefSeq:NM_001044588.1 FBXO32

Other Identifiers

733657

GO:0003012

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0014894

GO:0016567

GO:0019005

GO:0030018

GO:0036211

GO:0043226

GO:0071549

Ssc.4368.1.S1_at

Ssc.4368.3.S1_at

Participates

as a member of

F-box protein [cytosol] (Sus scrofa)

Inferred From

FBXO32 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001038053.1

OpenTargets

ENSG00000156804

Ensembl

ENSSSCP00000035710, ENSSSCT00000044541, ENSSSCG00000005981

VGNC

88039

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