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KDM4B [nucleoplasm]
Stable Identifier
R-SSC-3214396
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
nucleoplasm
Synonyms
KDM4B, I3LBN0
Locations in the PathwayBrowser
Expand all
Chromatin organization (Sus scrofa)
Chromatin modifying enzymes (Sus scrofa)
HDMs demethylate histones (Sus scrofa)
KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Sus scrofa)
KDM4A, KDM4B, KDM4C, KDM4D, MINA [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Sus scrofa)
KDM4A, KDM4B, KDM4C, KDM4D, MINA [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
DNA Repair (Sus scrofa)
DNA Double-Strand Break Repair (Sus scrofa)
DNA Double Strand Break Response (Sus scrofa)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Sus scrofa)
ATM phosphorylates HERC2 (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
HERC2 and PIAS4 are recruited to DNA DSBs (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
KDM4A,B bind H4K20Me2 (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
RNF168 binds DNA DSBs (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
RNF8 and RNF168 ubiquitinate H2AFX (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
RNF8 and RNF168 ubiquitinate KDM4A,B (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
RNF8 binds phosphorylated MDC1 at DNA DSBs (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Sus scrofa)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
Signal Transduction (Sus scrofa)
Signaling by Nuclear Receptors (Sus scrofa)
ESR-mediated signaling (Sus scrofa)
Estrogen-dependent gene expression (Sus scrofa)
ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Sus scrofa)
KDM4B [nucleoplasm] (Sus scrofa)
External Reference Information
External Reference
UniProt:I3LBN0
Gene Names
KDM4B
Reference Genes
ENSEMBL:ENSSSCG00000024570.4
Other Identifiers
100738761
GO:0003824
GO:0005634
GO:0005654
GO:0005694
GO:0005721
GO:0005829
GO:0006325
GO:0006338
GO:0007420
GO:0008270
GO:0016491
GO:0032452
GO:0032454
GO:0036211
GO:0043226
GO:0043229
GO:0046872
GO:0048856
GO:0051213
GO:0051864
GO:0140096
GO:0140684
Ssc.11336.1.S1_at
Ssc.27696.1.A1_at
Participates
as an output of
KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Sus scrofa)
as an input of
ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Sus scrofa)
as a component of
KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Sus scrofa)
as a member of
KDM4A, KDM4B, KDM4C, KDM4D, MINA [nucleoplasm] (Sus scrofa)
KDM4A,B [nucleoplasm] (Sus scrofa)
Other forms of this molecule
KDM4B [nucleoplasm]
Inferred From
KDM4B [nucleoplasm]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000127663
Ensembl
ENSSSCT00000041912
,
ENSSSCG00000024570
,
ENSSSCP00000047501
VGNC
89413
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