Reactome | ELMO2 [cytosol]

ELMO2 [cytosol]

Stable Identifier

R-SSC-372642

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

ELMO2, A0A286ZKS3

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - Regulation of actin dynamics for phagocytic cup formation (Sus scrofa)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Non-Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by PTK6 (Sus scrofa)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Sus scrofa)
      - Activation of RAC1 by the PXN:CRK complex (Sus scrofa)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
      - Phosphorylated PXN recruits the CRK complex (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by VEGF (Sus scrofa)
    - VEGFA-VEGFR2 Pathway (Sus scrofa)
      - DOCK180:ELMO binds CRK (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
        
        DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Sus scrofa)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO1,ELMO2 [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Sus scrofa)
  - Signaling by Rho GTPases (Sus scrofa)
    - RHO GTPase cycle (Sus scrofa)
      - RHOG GTPase cycle (Sus scrofa)
        
        RHOG binds effectors at the plasma membrane (Sus scrofa)
        
        RHOG plasma membrane effectors [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)
        
        RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Sus scrofa)
        
        RHOG plasma membrane effectors [cytosol] (Sus scrofa)
        
        ELMO2 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZKS3

Gene Names

ELMO2

Reference Genes

ENSEMBL:ENSSSCG00000023306.4

Other Identifiers

100624052

GO:0005737

GO:0005829

GO:0006909

GO:0006915

GO:0012501

GO:0016020

GO:0016192

GO:0017124

GO:0030971

GO:0048870

GO:0060326

Ssc.2298.1.S1_at

Participates

as a candidate of

RHOG plasma membrane effectors [cytosol] (Sus scrofa)

as a member of

ELMO1,ELMO2 [cytosol] (Sus scrofa)

Inferred From

ELMO2 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000062598

Ensembl

ENSSSCT00000058351, ENSSSCP00000048276, ENSSSCG00000023306

VGNC

95837