Reactome | CLIP1 [cytosol]

CLIP1 [cytosol]

Stable Identifier

R-SSC-377732

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

CLIP1, F1REW5

Locations in the PathwayBrowser

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Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - Mitotic Spindle Checkpoint (Sus scrofa)
    - Amplification of signal from the kinetochores (Sus scrofa)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Sus scrofa)
        
        MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Mad1 binds kinetochore (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Release of activated MAD2 from kinetochores (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - M Phase (Sus scrofa)
    - Mitotic Metaphase and Anaphase (Sus scrofa)
      - Mitotic Anaphase (Sus scrofa)
        
        Separation of Sister Chromatids (Sus scrofa)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Sus scrofa)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Separation of sister chromatids (Sus scrofa)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
    - Mitotic Prometaphase (Sus scrofa)
      - EML4 and NUDC in mitotic spindle formation (Sus scrofa)
        
        EML4 recruits NUDC to mitotic spindle (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
      - Kinetochore capture of astral microtubules (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
      - Resolution of Sister Chromatid Cohesion (Sus scrofa)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Kinetochore assembly (Sus scrofa)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        CLIP1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1REW5

Gene Names

CLIP1

Reference Genes

ENSEMBL:ENSSSCG00000009793

Other Identifiers

100153677

GO:0003674

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005856

GO:0007010

GO:0008092

GO:0008150

GO:0022607

GO:0031116

GO:0031122

GO:0035371

GO:0043226

GO:0051010

GO:0065003

Ssc.21890.1.S1_at

Ssc.24222.1.A1_at

Ssc.30898.1.S1_at

Participant Of

input

IQGAP1 binds CLIP1 and microtubules

hasComponent

Inferred From

CLIP1 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000130779

Ensembl

ENSSSCG00000009793, ENSSSCP00000010455, ENSSSCT00000010735

VGNC

86766

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