Reactome | FANCL [nucleoplasm]

FANCL [nucleoplasm]

Stable Identifier

R-SSC-419520

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

FANCL, A0A287B7H5

Locations in the PathwayBrowser

Expand all

DNA Repair (Sus scrofa)

- Fanconi Anemia Pathway (Sus scrofa)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Sus scrofa)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
  - DNA nucleases bind monoubiquitinated ID2 complex (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
  - FA core complex assembles at DNA interstrand crosslinks (ICLs) (Sus scrofa)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
    - FANCL [nucleoplasm] (Sus scrofa)
  - FANCD2 deubiquitination by USP1:WDR48 (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Sus scrofa)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
  - Monoubiquitination of FANCD2:FANCI (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
  - POLN binds ICL-DNA (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Sus scrofa)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
  - Translesion synthesis across unhooked ICL by POLN (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA core complex [nucleoplasm] (Sus scrofa)
        
        FANCL [nucleoplasm] (Sus scrofa)
    - p-FA Core Complex [nucleoplasm] (Sus scrofa)
      - FANCL [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287B7H5

Gene Names

FANCL

Reference Genes

ENSEMBL:ENSSSCG00000008394

Other Identifiers

100526164

GO:0000003

GO:0003674

GO:0004842

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005654

GO:0006259

GO:0006281

GO:0006464

GO:0006513

GO:0006950

GO:0006974

GO:0007276

GO:0008150

GO:0008283

GO:0016604

GO:0019899

GO:0031625

GO:0032991

GO:0034641

GO:0036297

GO:0042127

GO:0043226

GO:0043231

GO:0043240

GO:0061630

Ssc.22028.1.S1_at

Participant Of

input

FA core complex assembles at DNA interstrand crosslinks (ICLs)

hasComponent

Inferred From

FANCL [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000115392

Ensembl

ENSSSCG00000008394, ENSSSCT00000059199, ENSSSCP00000052056

Cite Us!