Reactome | FAAP24 [nucleoplasm]

FAAP24 [nucleoplasm]

Stable Identifier

R-SSC-419533

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

I3LHE7

Locations in the PathwayBrowser

Expand all

DNA Repair (Sus scrofa)

- Fanconi Anemia Pathway (Sus scrofa)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Sus scrofa)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
  - DNA nucleases bind monoubiquitinated ID2 complex (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA core complex [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
  - FA core complex assembles at DNA interstrand crosslinks (ICLs) (Sus scrofa)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
    - FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
  - FANCD2 deubiquitination by USP1:WDR48 (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Sus scrofa)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
  - FANCM binds FAAP24 (Sus scrofa)
    - FAAP24 [nucleoplasm] (Sus scrofa)
    - FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
      - FAAP24 [nucleoplasm] (Sus scrofa)
  - Monoubiquitination of FANCD2:FANCI (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        p-FA Core Complex [nucleoplasm] (Sus scrofa)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
  - POLN binds ICL-DNA (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA core complex [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA core complex [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Sus scrofa)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA Core Complex [nucleoplasm] (Sus scrofa)
        
        FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
  - Translesion synthesis across unhooked ICL by POLN (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Sus scrofa)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Sus scrofa)
        
        FA core complex [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)
    - p-FA Core Complex [nucleoplasm] (Sus scrofa)
      - p-S1045-FANCM:FAAP24 [nucleoplasm] (Sus scrofa)
        
        FAAP24 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3LHE7

Reference Genes

BioGPS Gene:100621643

ENSEMBL:ENSSSCG00000040905.3

ENSEMBL:ENSSSCG00005030828.1

KEGG Gene (Sus scrofa):100621643

Monarch:100621643

NCBI Gene:100621643

Reference Transcript

Other Identifiers

100621643

GO:0000785

GO:0003682

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0036297

GO:0043226

GO:0043231

GO:0043240

GO:0071821

Ssc.24208.1.S1_at

Ssc.28469.1.A1_at

Participates

as a component of

as an input of

FANCM binds FAAP24 (Sus scrofa)

Other forms of this molecule

FAAP24 [cytosol]

Inferred From

FAAP24 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_003355891.1, XP_003355892.1

Ensembl

ENSSSCT00000028553, ENSSSCP00000023493, ENSSSCG00000040905

VGNC

87870

Cite Us!