Reactome | Me2K-10-H3F3A [nucleoplasm]

Me2K-10-H3F3A [nucleoplasm]

Stable Identifier

R-SSC-427324

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

Q71LE2

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular Senescence (Sus scrofa)
    - Senescence-Associated Secretory Phenotype (SASP) (Sus scrofa)
      - EHMT1:EHMT2 methylates IL6 promoter (Sus scrofa)
        
        IL6 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)
      - EHMT1:EHMT2 methylates IL8 promoter (Sus scrofa)
        
        IL8 gene:Nucleosome-H3K9Me2 [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- Epigenetic regulation of gene expression (Sus scrofa)
  - Negative epigenetic regulation of rRNA expression (Sus scrofa)
    - NoRC negatively regulates rRNA expression (Sus scrofa)
      - MBD2 binds methylcytosine in chromatin (Sus scrofa)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Sus scrofa)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)
    - SIRT1 negatively regulates rRNA expression (Sus scrofa)
      - Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)
        
        eNoSC [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)
      - eNoSC deacetylates histone H3 (Sus scrofa)
        
        eNoSC [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)
      - eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)
        
        eNoSC [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)
- RNA Polymerase I Transcription (Sus scrofa)
  - RNA Polymerase I Promoter Clearance (Sus scrofa)
    - RNA Polymerase I Promoter Escape (Sus scrofa)
      - Elongation of pre-rRNA transcript (Sus scrofa)
        
        Chromatin (H3K9me2):CBX3 [nucleoplasm] (Sus scrofa)
        
        Chromatin (H3K9me2) [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)
    - RNA Polymerase I Promoter Opening (Sus scrofa)
      - UBF-1 Binds rDNA Promoter (Sus scrofa)
        
        Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Sus scrofa)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Sus scrofa)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Sus scrofa)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Sus scrofa)
        
        Me2K-10-H3F3A [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q71LE2

Reference Genes

BioGPS Gene:100521680

BioGPS Gene:396970

dbSNP Gene:100521680

dbSNP Gene:396970

ENSEMBL:ENSSSCG00000017202

ENSEMBL:ENSSSCG00000023971

KEGG Gene (Sus scrofa):100521680

KEGG Gene (Sus scrofa):396970

Monarch:100521680

Monarch:396970

NCBI Gene:100521680

NCBI Gene:396970

Reference Transcript

Other Identifiers

100521680

396970

A0A286ZLA0

AAL76273

AF469469

ENSSSCG00000017202

ENSSSCG00000023971

ENSSSCP00000018225

ENSSSCP00000026784

ENSSSCP00000038153

ENSSSCP00000038252

ENSSSCT00000018727

ENSSSCT00000022867

ENSSSCT00000049322

ENSSSCT00000050448

EntrezGene:100521680

EntrezGene:396970

EntrezGene:H3F3A

EntrezGene:H3F3A-201

EntrezGene:H3F3A-202

EntrezGene:H3F3A-203

EntrezGene:LOC100521680

GACC01000065

GO:0000786

GO:0003674

GO:0003677

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005694

GO:0031492

GO:0032991

GO:0043226

GO:0046982

H3F3A

H3F3B

H3F3B-202

HGNC:4765

IPR000164

IPR007125

IPR009072

JAA53742

K9IWF3

LOC100521680

NM_213930

NP_999095

PF00125

PR00622

SM00428

Ssc.10940.1.S1_at

Ssc.11548.1.S1_at

Ssc.11548.1.S2_at

UPI00000007B0

XM_003131194

XP_003131242

Participant Of

hasMember

Histone H3 dimethylated at lysine-9 [nucleoplasm]

Other forms of this molecule

MeK-H3F3A [nucleoplasm]

2xAcK-H3F3A [nucleoplasm]

Me2K5,Me2aR2-H3F3A [nucleoplasm]

AcK10-H3F3A [nucleoplasm]

phospho-p-T12-H3F3A [nucleoplasm]

phospho-p-T12,MeK-H3F3A [nucleoplasm]

p-T12, Me2K-10-H3F3A [nucleoplasm]

Me3K-10-H3F3A [nucleoplasm]

phospho-p-T12,Me3K-10-H3F3A [nucleoplasm]

Me3K5-H3F3A [nucleoplasm]

H3F3A [nucleoplasm]

Me3K-28-H3F3A [nucleoplasm]

Me2K5-H3F3A [nucleoplasm]

Inferred From

Me2K-10-H3F3A [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6-dimethyl-L-lysine at 10 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6-dimethyl-L-lysine [MOD:00084]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.

Cross References

RefSeq

NP_999095.1, XP_003131242.1