Reactome | IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane]

IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane]

Stable Identifier

R-SSC-446643

Type

Complex

Species

Sus scrofa

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

IL1R1:IL1:IL1RAP [plasma membrane] (Sus scrofa)
MYD88 dimer [cytosol] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
TOLLIP [cytosol] (Sus scrofa)

Participates

as an output of

IRAK4 is activated by autophosphorylation (Sus scrofa)

as an input of

IRAK1 binds to MYD88 within the IL1R complex (Sus scrofa)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Sus scrofa)

as a component of

IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Sus scrofa)

Inferred From

IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)

Cite Us!