Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-p-T342,T345,S346-IRAK4 [cytosol]
Stable Identifier
R-SSC-446649
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
F6Q7E6
Locations in the PathwayBrowser
Expand all
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
Signaling by Interleukins (Sus scrofa)
Interleukin-1 family signaling (Sus scrofa)
Interleukin-1 signaling (Sus scrofa)
Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
IRAK1 binds to MYD88 within the IL1R complex (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
IRAK4 is activated by autophosphorylation (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
IRAK4 phosphorylates IRAK1 (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
IRAK4-activated IRAK1 autophosphorylates (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
TRAF6 binding leads to IRAK1:TRAF6 release (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Sus scrofa)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:F6Q7E6
Reference Genes
ENSEMBL:ENSSSCG00000000799.6
Other Identifiers
100127166
GO:0000166
GO:0000287
GO:0002376
GO:0002446
GO:0003824
GO:0004672
GO:0004674
GO:0005149
GO:0005524
GO:0005634
GO:0005737
GO:0005886
GO:0007165
GO:0008063
GO:0009986
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019901
GO:0023052
GO:0035556
GO:0038172
GO:0043123
GO:0043226
GO:0045087
GO:0048870
GO:0070498
GO:0071222
GO:0098542
GO:0140096
GO:1990266
Participates
as an output of
TRAF6 binding leads to IRAK1:TRAF6 release (Sus scrofa)
as a component of
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Sus scrofa)
Other forms of this molecule
IRAK4 [cytosol]
Inferred From
p-T342,T345,S346-IRAK4 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 342 (in Homo sapiens)
Coordinate
342
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 345 (in Homo sapiens)
Coordinate
345
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 346 (in Homo sapiens)
Coordinate
346
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
Ensembl
ENSSSCT00000000866
,
ENSSSCG00000000799
,
ENSSSCP00000000849
VGNC
89202
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text