Reactome | phospho-JAK1 [cytosol]

phospho-JAK1 [cytosol]

Stable Identifier

R-SSC-451921

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

p-Y-JAK1, A0A286ZLI2

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Interferon Signaling (Sus scrofa)
    - Interferon gamma signaling (Sus scrofa)
      - Phosphorylation of IFNGR1 by JAK kinases (Sus scrofa)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IFNGR complex with p-JAK [plasma membrane] (Sus scrofa)
        
        IFNGR1:p-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Sus scrofa)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Sus scrofa)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - Transphosphorylation of JAK1 (Sus scrofa)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IFNGR complex with p-JAK [plasma membrane] (Sus scrofa)
        
        IFNGR1:p-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
  - Signaling by CSF3 (G-CSF) (Sus scrofa)
    - Inactivation of CSF3 (G-CSF) signaling (Sus scrofa)
      - CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Sus scrofa)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Sus scrofa)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Sus scrofa)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Sus scrofa)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Sus scrofa)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [lysosomal membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Sus scrofa)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Sus scrofa)
        
        CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        CSF3 dimer:K48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        K48polyUb-K655, p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Sus scrofa)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Sus scrofa)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Sus scrofa)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [endocytic vesicle membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
    - p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Sus scrofa)
      - CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Sus scrofa)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Sus scrofa)
        
        CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-10 signaling (Sus scrofa)
      - IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - JAK1,TYK2 phosphorylate JAK1,TYK2 (Sus scrofa)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Sus scrofa)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Sus scrofa)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
    - Interleukin-2 family signaling (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Sus scrofa)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - Interleukin-15 signaling (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - Interleukin-21 signaling (Sus scrofa)
        
        IL21 receptor JAK phosphorylation (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL21 receptor STAT binding (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL21 receptor STAT phosphorylation (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Sus scrofa)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
    - Interleukin-4 and Interleukin-13 signaling (Sus scrofa)
      - IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - JAK1 phosphorylates STAT3,STAT6 (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - STAT3,STAT6 bind p-Y-IL4R (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
      - p-Y705-STAT3,p-Y641-STAT6 dissociate (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Sus scrofa)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-JAK1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZLI2

Gene Names

JAK1

Reference Genes

ENSEMBL:ENSSSCG00000003809

Other Identifiers

397202

GO:0003674

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0007155

GO:0007165

GO:0008150

GO:0019899

GO:0019903

GO:0031625

GO:0034112

GO:0038110

GO:0043226

GO:0046677

GO:0048646

GO:0048856

GO:0150105

GO:1903672

Ssc.328.1.A1_at

Participates

as a component of

Other forms of this molecule

phospho-JAK1 [cytosol]

JAK1 [endosome]

phospho-JAK1 [cytosol]

JAK1 [cytosol]

Inferred From

p-Y-JAK1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000162434

Ensembl

ENSSSCT00000045514, ENSSSCG00000003809, ENSSSCP00000032415

VGNC

89270

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