Reactome | phospho-p-Y-JAK1 [cytosol]

phospho-p-Y-JAK1 [cytosol]

Stable Identifier

R-SSC-451921

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

K7GME4

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Interferon Signaling (Sus scrofa)
    - Interferon gamma signaling (Sus scrofa)
      - Phosphorylation of IFNGR1 by JAK kinases (Sus scrofa)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IFNGR complex with p-JAK [plasma membrane] (Sus scrofa)
        
        IFNGR1:p-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Sus scrofa)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Sus scrofa)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
      - Transphosphorylation of JAK1 (Sus scrofa)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Sus scrofa)
        
        IFNGR complex with p-JAK [plasma membrane] (Sus scrofa)
        
        IFNGR1:p-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-2 family signaling (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
      - Interleukin-15 signaling (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Sus scrofa)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
      - Interleukin-21 signaling (Sus scrofa)
        
        IL21 receptor JAK phosphorylation (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL21 receptor STAT binding (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL21 receptor STAT phosphorylation (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Sus scrofa)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Sus scrofa)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Sus scrofa)
        
        phospho-p-Y-JAK1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:K7GME4

Reference Genes

ENSEMBL:ENSSSCG00000003809

Participant Of

hasComponent

Other forms of this molecule

phospho-p-Y1022,Y1023-JAK1 [cytosol]

JAK1 [endosome]

phospho-p-JAK1 [cytosol]

JAK1 [cytosol]

Inferred From

p-Y-JAK1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

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