Reactome | GAB2 [cytosol]

GAB2 [cytosol]

Stable Identifier

R-SSC-508239

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

GAB2, A0A287B630

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-2 family signaling (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Sus scrofa)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Sus scrofa)
        
        GRB2:GAB2 [cytosol] (Sus scrofa)
        
        GAB2 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287B630

Gene Names

GAB2

Reference Genes

ENSEMBL:ENSSSCG00000014891.5

Other Identifiers

100513609

GO:0005068

GO:0005737

GO:0005886

GO:0007165

GO:0007169

GO:0008284

GO:0023052

GO:0030154

GO:0030316

GO:0048856

GO:0060090

Ssc.26599.1.A1_at

Participates

as a member of

GAB1,GAB2 [cytosol] (Sus scrofa)

as a component of

as an input of

Indirect recruitment of GAB2 to p-KIT (Sus scrofa)

Other forms of this molecule

phospho-GAB2 [cytosol]

Inferred From

GAB2 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000033327

Ensembl

ENSSSCT00000063586, ENSSSCP00000051969, ENSSSCG00000014891

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