Reactome | BIRC5 [cytosol]

BIRC5 [cytosol]

Stable Identifier

R-SSC-50851

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

Q9GLN5

Locations in the PathwayBrowser

Expand all

Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - Mitotic Spindle Checkpoint (Sus scrofa)
    - Amplification of signal from the kinetochores (Sus scrofa)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Sus scrofa)
        
        MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Mad1 binds kinetochore (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Release of activated MAD2 from kinetochores (Sus scrofa)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Mad1:kinetochore complex [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - M Phase (Sus scrofa)
    - Mitotic Metaphase and Anaphase (Sus scrofa)
      - Mitotic Anaphase (Sus scrofa)
        
        Separation of Sister Chromatids (Sus scrofa)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Sus scrofa)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Separation of sister chromatids (Sus scrofa)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
    - Mitotic Prometaphase (Sus scrofa)
      - EML4 and NUDC in mitotic spindle formation (Sus scrofa)
        
        EML4 recruits NUDC to mitotic spindle (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
      - Kinetochore capture of astral microtubules (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
      - Resolution of Sister Chromatid Cohesion (Sus scrofa)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Kinetochore assembly (Sus scrofa)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Sus scrofa)
        
        Microtubule-bound kinetochore [cytosol] (Sus scrofa)
        
        Kinetochore [cytosol] (Sus scrofa)
        
        Chromosome passenger complex [cytosol] (Sus scrofa)
        
        BIRC5 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q9GLN5

Reference Genes

BioGPS Gene:397266

ENSEMBL:ENSSSCG00000040486.3

ENSEMBL:ENSSSCG00015047349.1

ENSEMBL:ENSSSCG00025054674.1

ENSEMBL:ENSSSCG00030008392.1

ENSEMBL:ENSSSCG00035044795.1

ENSEMBL:ENSSSCG00040003906.1

ENSEMBL:ENSSSCG00045032699.1

ENSEMBL:ENSSSCG00050047226.1

ENSEMBL:ENSSSCG00055006534.1

ENSEMBL:ENSSSCG00060056330.1

ENSEMBL:ENSSSCG00065003092.1

ENSEMBL:ENSSSCG00070019114.1

KEGG Gene (Sus scrofa):397266

Monarch:397266

NCBI Gene:397266

Reference Transcript

RefSeq:NM_214141.1

Other Identifiers

397266

GO:0000226

GO:0000278

GO:0000775

GO:0005694

GO:0005737

GO:0007010

GO:0007127

GO:0007346

GO:0012501

GO:0022414

GO:0023052

GO:0043066

GO:0043226

GO:0043524

GO:0061178

GO:0061469

GO:0140013

Ssc.2712.1.S1_at

Ssc.432.1.S1_at

Participates

as an input of

CUL9:RBX1 ubiquitinates BIRC5 (Sus scrofa)

as a component of

Other forms of this molecule

ub-BIRC5 [cytosol]

BIRC5 [nucleoplasm]

Inferred From

BIRC5 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_999306.1

Ensembl

ENSSSCP00000042198, ENSSSCT00000043788, ENSSSCG00000040486

VGNC

85827

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