Reactome | ADCY8 [plasma membrane]

ADCY8 [plasma membrane]

Stable Identifier

R-SSC-53245

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

A0A287AWF4

Locations in the PathwayBrowser

Expand all

Neuronal System (Sus scrofa)

- Transmission across Chemical Synapses (Sus scrofa)
  - Neurotransmitter receptors and postsynaptic signal transmission (Sus scrofa)
    - GABA receptor activation (Sus scrofa)
      - GABA B receptor activation (Sus scrofa)
        
        Activation of GABAB receptors (Sus scrofa)
        
        Adenylate cyclase inhibitory pathway (Sus scrofa)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        Dissociation of the Gi alpha:G olf complex (Sus scrofa)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - DAG and IP3 signaling (Sus scrofa)
    - CaM pathway (Sus scrofa)
      - Calmodulin induced events (Sus scrofa)
        
        PKA-mediated phosphorylation of CREB (Sus scrofa)
        
        PKA activation (Sus scrofa)
        
        Adenylate cyclase produces cAMP (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (i) signalling events (Sus scrofa)
      - Opioid Signalling (Sus scrofa)
        
        G-protein mediated events (Sus scrofa)
        
        Adenylate cyclase activating pathway (Sus scrofa)
        
        Adenylate cyclase converts ATP into cyclic AMP (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        Adenylaye cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        Galpha-olf:GTP binds to adenylate cyclase and activates it (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GTP:Adenylate cyclase (active) complex [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GDP:Adenylate cyclase (active) complex [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase inhibitory pathway (Sus scrofa)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        Dissociation of the Gi alpha:G olf complex (Sus scrofa)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Sus scrofa)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        PLC beta mediated events (Sus scrofa)
        
        Ca-dependent events (Sus scrofa)
        
        CaM pathway (Sus scrofa)
        
        Calmodulin induced events (Sus scrofa)
        
        PKA-mediated phosphorylation of CREB (Sus scrofa)
        
        PKA activation (Sus scrofa)
        
        Adenylate cyclase produces cAMP (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
    - G alpha (z) signalling events (Sus scrofa)
      - G alpha (z) inhibits adenylate cyclase (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
        
        G-protein alpha (z):GTP:Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase (Mg2+ cofactor) [plasma membrane] (Sus scrofa)
        
        Adenylate cyclase [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)
- Signaling by Hedgehog (Sus scrofa)
  - Hedgehog 'off' state (Sus scrofa)
    - GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Sus scrofa)
      - adenylate cyclases:Mg2+ [plasma membrane] (Sus scrofa)
        
        adenylate cyclases [plasma membrane] (Sus scrofa)
        
        ADCY8 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287AWF4

Reference Genes

ENSEMBL:ENSSSCG00000031717.3

Other Identifiers

100622999

GO:0003824

GO:0004016

GO:0005886

GO:0006954

GO:0007189

GO:0007613

GO:0007616

GO:0007626

GO:0008294

GO:0009975

GO:0010255

GO:0014069

GO:0016323

GO:0016324

GO:0016829

GO:0023052

GO:0030424

GO:0030425

GO:0031915

GO:0032024

GO:0032809

GO:0035774

GO:0042593

GO:0042734

GO:0043226

GO:0048786

GO:0050804

GO:0050877

GO:0051480

GO:0055065

GO:0060076

GO:0071315

GO:0071377

GO:0080135

GO:0098685

GO:0098686

GO:0098978

GO:0150076

GO:1900273

GO:1900454

Participates

as a candidate of

adenylate cyclases [plasma membrane] (Sus scrofa)

as a member of

Adenylate cyclase [plasma membrane] (Sus scrofa)

Inferred From

ADCY8 [plasma membrane] (Homo sapiens)

Cross References

Ensembl

ENSSSCG00000031717, ENSSSCP00000048237, ENSSSCT00000061510

VGNC

85112

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