Reactome: A Curated Pathway Database

EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch

Stable Identifier
R-SSC-5358599
Type
Reaction [BlackBoxEvent]
Species
Sus scrofa
Compartment
Locations in the PathwayBrowser
Summation

This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
5'-3' exonuclease activity of EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] 5'-3' exonuclease activity (0008409)
Inferred From