Reactome | SPOPL [nucleoplasm]

SPOPL [nucleoplasm]

Stable Identifier

R-SSC-5635036

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

SPOPL, A0A287AS40

Locations in the PathwayBrowser

Expand all

Signal Transduction (Sus scrofa)

- Signaling by Hedgehog (Sus scrofa)
  - Hedgehog 'on' state (Sus scrofa)
    - GLI2,3 are degraded by the proteasome (Sus scrofa)
      - SPOP:CUL3:RBX1 [nucleoplasm] (Sus scrofa)
        
        SPOP dimer [nucleoplasm] (Sus scrofa)
        
        SPOP:SPOPL [nucleoplasm] (Sus scrofa)
        
        SPOPL [nucleoplasm] (Sus scrofa)
      - ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Sus scrofa)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Sus scrofa)
        
        SPOP dimer [nucleoplasm] (Sus scrofa)
        
        SPOP:SPOPL [nucleoplasm] (Sus scrofa)
        
        SPOPL [nucleoplasm] (Sus scrofa)
    - SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Sus scrofa)
      - 2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Sus scrofa)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Sus scrofa)
        
        SPOP dimer [nucleoplasm] (Sus scrofa)
        
        SPOP:SPOPL [nucleoplasm] (Sus scrofa)
        
        SPOPL [nucleoplasm] (Sus scrofa)
      - ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Sus scrofa)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Sus scrofa)
        
        SPOP dimer [nucleoplasm] (Sus scrofa)
        
        SPOP:SPOPL [nucleoplasm] (Sus scrofa)
        
        SPOPL [nucleoplasm] (Sus scrofa)
    - phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Sus scrofa)
      - 2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Sus scrofa)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Sus scrofa)
        
        SPOP dimer [nucleoplasm] (Sus scrofa)
        
        SPOP:SPOPL [nucleoplasm] (Sus scrofa)
        
        SPOPL [nucleoplasm] (Sus scrofa)
      - SPOP:CUL3:RBX1 [nucleoplasm] (Sus scrofa)
        
        SPOP dimer [nucleoplasm] (Sus scrofa)
        
        SPOP:SPOPL [nucleoplasm] (Sus scrofa)
        
        SPOPL [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287AS40

Gene Names

SPOPL

Reference Genes

BioGPS Gene:100156406 SPOPL

ENSEMBL:ENSSSCG00000032198.3

ENSEMBL:ENSSSCG00005036458.1 SPOPL

KEGG Gene (Sus scrofa):100156406 SPOPL

Monarch:100156406 SPOPL

NCBI Gene:100156406 SPOPL

Reference Transcript

RefSeq:XM_001924688.5 SPOPL

Other Identifiers

100156406

GO:0005515

GO:0005634

GO:0005737

GO:0030162

GO:0030163

GO:0031397

GO:0031463

GO:0031625

GO:0036211

GO:0043161

GO:0043226

Ssc.24334.1.S1_at

Participates

as a component of

SPOP:SPOPL [nucleoplasm] (Sus scrofa)

Inferred From

SPOPL [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_001924723.1

OpenTargets

ENSG00000144228

Ensembl

ENSSSCG00000032198, ENSSSCT00000059167, ENSSSCP00000046883

VGNC

96161

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