Reactome | phospho-ARAF [plasma membrane]

phospho-ARAF [plasma membrane]

Stable Identifier

R-SSC-5672648

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

p-S299,S302,T452,T455,S576 ARAF, O19004

Locations in the PathwayBrowser

Expand all

Signal Transduction (Sus scrofa)

- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - MAP2K and MAPK activation (Sus scrofa)
        
        Dissociation of RAS:RAF complex (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        MAP2Ks phosphorylate MAPKs (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        RAF phosphorylates MAP2K dimer (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Sus scrofa)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Sus scrofa)
        
        activated RAF/KSR1 [plasma membrane] (Sus scrofa)
        
        phospho-ARAF [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:O19004

Gene Names

ARAF

Reference Genes

BioGPS Gene:397601 ARAF

ENSEMBL:ENSSSCG00000012275

ENSEMBL:ENSSSCG00065077117 ARAF

ENSEMBL:ENSSSCG00070007562 ARAF

KEGG Gene (Sus scrofa):397601 ARAF

Monarch:397601 ARAF

NCBI Gene:397601 ARAF

Reference Transcript

Participant Of

hasCandidate

activated RAF/KSR1 [plasma membrane]

Other forms of this molecule

phospho-ARAF [cytosol]

Inferred From

p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 576 (in Homo sapiens)

Coordinate

576

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 299 (in Homo sapiens)

Coordinate

299

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 302 (in Homo sapiens)

Coordinate

302

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-threonine at 452 (in Homo sapiens)

Coordinate

452

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 455 (in Homo sapiens)

Coordinate

455

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_005657855.1, NP_999494.1

OpenTargets

ENSG00000078061

Cite Us!