Reactome | EME2 [nucleoplasm]

EME2 [nucleoplasm]

Stable Identifier

R-SSC-5686438

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

EME2, I3LE59

Locations in the PathwayBrowser

Expand all

DNA Repair (Sus scrofa)

- DNA Double-Strand Break Repair (Sus scrofa)
  - Homology Directed Repair (Sus scrofa)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
      - HDR through Homologous Recombination (HRR) (Sus scrofa)
        
        Resolution of D-Loop Structures (Sus scrofa)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Sus scrofa)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Sus scrofa)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2),GEN1 [nucleoplasm] (Sus scrofa)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME2 [nucleoplasm] (Sus scrofa)
        
        EME2 [nucleoplasm] (Sus scrofa)
        
        MUS81 binds EME1, EME2 (Sus scrofa)
        
        EME1,EME2 [nucleoplasm] (Sus scrofa)
        
        EME2 [nucleoplasm] (Sus scrofa)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME2 [nucleoplasm] (Sus scrofa)
        
        EME2 [nucleoplasm] (Sus scrofa)
        
        MUS81:EME1,EME2 cleaves D-loop (Sus scrofa)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME2 [nucleoplasm] (Sus scrofa)
        
        EME2 [nucleoplasm] (Sus scrofa)
        
        SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Sus scrofa)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME2 [nucleoplasm] (Sus scrofa)
        
        EME2 [nucleoplasm] (Sus scrofa)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME2 [nucleoplasm] (Sus scrofa)
        
        EME2 [nucleoplasm] (Sus scrofa)
- Fanconi Anemia Pathway (Sus scrofa)
  - DNA nucleases bind monoubiquitinated ID2 complex (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME2 [nucleoplasm] (Sus scrofa)
        
        EME2 [nucleoplasm] (Sus scrofa)
    - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Sus scrofa)
      - MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME2 [nucleoplasm] (Sus scrofa)
        
        EME2 [nucleoplasm] (Sus scrofa)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Sus scrofa)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Sus scrofa)
      - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME2 [nucleoplasm] (Sus scrofa)
        
        EME2 [nucleoplasm] (Sus scrofa)
    - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Sus scrofa)
      - MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Sus scrofa)
        
        MUS81:EME2 [nucleoplasm] (Sus scrofa)
        
        EME2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3LE59

Gene Names

EME2

Reference Genes

ENSEMBL:ENSSSCG00000021467.3

Other Identifiers

100521548

GO:0003677

GO:0003824

GO:0004518

GO:0005634

GO:0006260

GO:0006281

GO:0006302

GO:0006310

GO:0006974

GO:0016787

GO:0031297

GO:0043226

GO:0048476

GO:1905347

Participates

as a candidate of

EME1,EME2 [nucleoplasm] (Sus scrofa)

as a component of

MUS81:EME2 [nucleoplasm] (Sus scrofa)

Inferred From

EME2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000197774

Ensembl

ENSSSCP00000022345, ENSSSCG00000021467, ENSSSCT00000028167

VGNC

87677