Reactome | CD59 [ER to Golgi transport vesicle membrane]

CD59 [ER to Golgi transport vesicle membrane]

Stable Identifier

R-SSC-5689801

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

ER to Golgi transport vesicle membrane

Synonyms

GPI-CD59, O62680

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Asparagine N-linked glycosylation (Sus scrofa)
    - Transport to the Golgi and subsequent modification (Sus scrofa)
      - ER to Golgi Anterograde Transport (Sus scrofa)
        
        COPII-mediated vesicle transport (Sus scrofa)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Sus scrofa)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        Nucleotide exchange on RAB1 (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        Vesicle budding (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - ER to Golgi Anterograde Transport (Sus scrofa)
    - COPII-mediated vesicle transport (Sus scrofa)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Sus scrofa)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)
      - Nucleotide exchange on RAB1 (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)
      - Vesicle budding (Sus scrofa)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)
        
        CD59 [ER to Golgi transport vesicle membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:O62680

Gene Names

CD59

Reference Genes

BioGPS Gene:397347 CD59

ENSEMBL:ENSSSCG00000024791

ENSEMBL:ENSSSCG00005042427 CD59

ENSEMBL:ENSSSCG00025018939 CD59

ENSEMBL:ENSSSCG00035054075 CD59

ENSEMBL:ENSSSCG00040062263 CD59

ENSEMBL:ENSSSCG00045033618 CD59

ENSEMBL:ENSSSCG00050038907 CD59

ENSEMBL:ENSSSCG00055013062 CD59

ENSEMBL:ENSSSCG00060031379 CD59

ENSEMBL:ENSSSCG00065028199 CD59

KEGG Gene (Sus scrofa):397347 CD59

Monarch:397347 CD59

NCBI Gene:397347 CD59

Reference Transcript

Other Identifiers

397347

GO:0001848

GO:0001971

GO:0002376

GO:0005886

GO:0016020

GO:0045087

GO:0098542

Ssc.16055.1.S1_at

Ssc.20559.1.A1_at

Participates

as a member of

GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Sus scrofa)

Other forms of this molecule

CD59 [tertiary granule membrane]

CD59 [specific granule membrane]

CD59 [Golgi membrane]

CD59 [transport vesicle]

CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane]

CD59 [endoplasmic reticulum membrane]

CD59 [plasma membrane]

Inferred From

GPI-CD59 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Modified Residues

Name

L-asparagine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 102 (in Homo sapiens)

Coordinate

102

Modification

GPI-anchor amidated amino acid carboxyl end residue(1−)

PsiMod Name

L-asparagine amide

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to L-asparagine amide.

Cross References

RefSeq

NP_999335.1, XP_005661088.1

OpenTargets

ENSG00000085063

Ensembl

ENSSSCG00000024791, ENSSSCP00000025898, ENSSSCT00000026025

VGNC

99615

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