Reactome | NDUFA8 [mitochondrial inner membrane]

NDUFA8 [mitochondrial inner membrane]

Stable Identifier

R-SSC-60627

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

mitochondrial inner membrane

Synonyms

NDUFA8, F1SLR1

Locations in the PathwayBrowser

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Metabolism (Sus scrofa)

- Aerobic respiration and respiratory electron transport (Sus scrofa)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Sus scrofa)
    - Respiratory electron transport (Sus scrofa)
      - Complex I biogenesis (Sus scrofa)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        980kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Sus scrofa)
        
        980kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
        
        Complex I [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Sus scrofa)
        
        Complex I [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        HP subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFA8 [mitochondrial inner membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SLR1

Gene Names

NDUFA8

Reference Genes

ENSEMBL:ENSSSCG00000005528.5

Other Identifiers

100154443

GO:0005739

GO:0005747

GO:0005758

GO:0006091

GO:0006120

GO:0043226

GO:0070469

Ssc.1108.1.S1_at

Participates

as a component of

HP subcomplex [mitochondrial inner membrane] (Sus scrofa)

Inferred From

NDUFA8 [mitochondrial inner membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000119421

Ensembl

ENSSSCT00000006079, ENSSSCG00000005528, ENSSSCP00000005924

VGNC

103139

PDB

7W1O, 7VYG, 7W1T, 7VWL, 7W20, 7V31, 7V2R, 7W1V, 7W4L, 7VY9, 7W2Y, 7W4N, 5GUP, 7VZW, 7VBP, 7W4D, 7W0R, 7W2K, 7V2D, 7W4F, 7W2R, 7W4J, 7W32, 7VXS, 7W1Z, 7V2K, 7VZ8, 7V30, 7W1P, 7VYE, 7V32, 7W1U, 7VYI, 7V33, 7W35, 7W4M, 7VZV, 7VBL, 7W4Q, 7W00, 7VC0, 7V2E, 7W4C, 7V2F, 7W4E, 7W2L, 7V2C, 7W4G, 7V3M, 7W0Y, 7W31, 7VY1, 7W2U, 7W4K, 5GPN, 7VYS, 7W0H, 7V2H

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