Reactome | PTEN [nucleoplasm]

PTEN [nucleoplasm]

Stable Identifier

R-SSC-6782515

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

PolyUb-PTEN, F2Z5H1

Locations in the PathwayBrowser

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Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Deubiquitination (Sus scrofa)
    - Ub-specific processing proteases (Sus scrofa)
      - USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)
        
        USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Sus scrofa)
        
        PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Sus scrofa)
        
        PTEN [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F2Z5H1

Gene Names

PTEN

Reference Genes

ENSEMBL:ENSSSCG00000010440

Other Identifiers

100156264

GO:0003674

GO:0004725

GO:0006464

GO:0006470

GO:0008138

GO:0008150

GO:0016311

GO:0016791

GO:0035335

Ssc.7652.1.A1_at

Participant Of

hasMember

PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm]

Other forms of this molecule

PTEN [cytosol]

PTEN [nucleoplasm]

PTEN [cytosol]

phospho-PTEN [cytosol]

PTEN [cytosol]

phospho-PTEN [cytosol]

PTEN [cytosol]

PTEN [nucleoplasm]

PTEN [cytosol]

Inferred From

PolyUb-PTEN [nucleoplasm] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

OpenTargets

ENSG00000171862

Ensembl

ENSSSCP00000011128, ENSSSCG00000010440, ENSSSCT00000011425

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