Reactome | NDUFS8 [mitochondrial matrix]

NDUFS8 [mitochondrial matrix]

Stable Identifier

R-SSC-6788526

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

mitochondrial matrix

Synonyms

NDUFS8, A0A286ZUN9

Locations in the PathwayBrowser

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Metabolism (Sus scrofa)

- Aerobic respiration and respiratory electron transport (Sus scrofa)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Sus scrofa)
    - Respiratory electron transport (Sus scrofa)
      - Complex I biogenesis (Sus scrofa)
        
        IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        NDUF subunits bind to form the IP subcomplex (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        NUBPL transfers 4Fe-4S to Complex I subunits (Sus scrofa)
        
        NDUF subunits [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        NDUF:4Fe-4S subunits [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        980kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Sus scrofa)
        
        980kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 [mitochondrial inner membrane] (Sus scrofa)
        
        IP subcomplex [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
        
        Complex I [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Sus scrofa)
        
        Complex I [mitochondrial inner membrane] (Sus scrofa)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Sus scrofa)
        
        NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)
        
        NDUFS8 [mitochondrial matrix] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A286ZUN9

Gene Names

NDUFS8

Reference Genes

BioGPS Gene:100521945 NDUFS8

ENSEMBL:ENSSSCG00000037455.3

KEGG Gene (Sus scrofa):100521945 NDUFS8

Monarch:100521945 NDUFS8

NCBI Gene:100521945 NDUFS8

Reference Transcript

RefSeq:XM_003122434.2 NDUFS8

Other Identifiers

100521945

GO:0003824

GO:0003954

GO:0005215

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0006979

GO:0007005

GO:0008137

GO:0016020

GO:0016491

GO:0016651

GO:0032981

GO:0043226

GO:0051539

GO:0065003

Ssc.2312.1.S1_at

Participates

as a member of

NDUF subunits [mitochondrial matrix] (Sus scrofa)

as a component of

NDUFS8:2x4Fe-4S [mitochondrial matrix] (Sus scrofa)

Inferred From

NDUFS8 [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

XP_003122482.1

OpenTargets

ENSG00000110717

Ensembl

ENSSSCT00000058116, ENSSSCG00000037455, ENSSSCP00000035370

VGNC

90656

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