Reactome | phospho-PolyUb,p-S166,S188-MDM2 [nucleoplasm]

phospho-PolyUb,p-S166,S188-MDM2 [nucleoplasm]

Stable Identifier

R-SSC-6795669

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

A0A287BEY7

Locations in the PathwayBrowser

Expand all

Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G1/S DNA Damage Checkpoints (Sus scrofa)
    - p53-Dependent G1/S DNA damage checkpoint (Sus scrofa)
      - p53-Dependent G1 DNA Damage Response (Sus scrofa)
        
        Stabilization of p53 (Sus scrofa)
        
        MDM2 ubiquitinates phosphorylated MDM4 (Sus scrofa)
        
        PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Sus scrofa)
        
        phospho-PolyUb,p-S166,S188-MDM2 [nucleoplasm] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Deubiquitination (Sus scrofa)
    - Ub-specific processing proteases (Sus scrofa)
      - USP2 deubiquitinates MDM2,MDM4 (Sus scrofa)
        
        USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Sus scrofa)
        
        PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Sus scrofa)
        
        phospho-PolyUb,p-S166,S188-MDM2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287BEY7

Reference Genes

ENSEMBL:ENSSSCG00000000488

Other Identifiers

100125959

GO:0000122

GO:0000278

GO:0001568

GO:0001974

GO:0002027

GO:0002039

GO:0003013

GO:0003170

GO:0003181

GO:0003203

GO:0003281

GO:0003283

GO:0003674

GO:0003723

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0006464

GO:0006511

GO:0006950

GO:0006977

GO:0007049

GO:0007089

GO:0007165

GO:0007507

GO:0008097

GO:0008150

GO:0008219

GO:0008270

GO:0009056

GO:0009058

GO:0010468

GO:0016567

GO:0016604

GO:0016740

GO:0016874

GO:0018205

GO:0019843

GO:0019899

GO:0019904

GO:0022607

GO:0030154

GO:0031625

GO:0031648

GO:0032182

GO:0032436

GO:0032991

GO:0034504

GO:0034641

GO:0042176

GO:0042802

GO:0043021

GO:0043066

GO:0043130

GO:0043167

GO:0043226

GO:0043518

GO:0045184

GO:0045787

GO:0045892

GO:0045931

GO:0046677

GO:0046872

GO:0047485

GO:0048856

GO:0051149

GO:0051603

GO:0051865

GO:0060411

GO:0061630

GO:0061663

GO:0065003

GO:0071157

GO:0071456

GO:0071480

GO:0072717

GO:0097110

GO:0097718

GO:1901797

GO:1902254

GO:1990000

Ssc.30116.1.A1_at

Participant Of

hasComponent

Other forms of this molecule

PolyUb-MDM2 [nucleoplasm]

SUMO1-K182-MDM2 [nucleoplasm]

MDM2 [plasma membrane]

MDM2 [endocytic vesicle membrane]

phospho-p-S166,S188,T218-MDM2 [nucleoplasm]

phospho-p-5S,T-MDM2 [nucleoplasm]

MDM2 [nucleoplasm]

MDM2 [cytosol]

phospho-p-S166,S188-MDM2 [cytosol]

phospho-p-S166,S188-MDM2 [nucleoplasm]

Inferred From

PolyUb,p-S166,S188-MDM2 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 166 (in Homo sapiens)

Coordinate

166

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 188 (in Homo sapiens)

Coordinate

188

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position

Modification

PolyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

Ensembl

ENSSSCT00000040827, ENSSSCP00000054644, ENSSSCG00000000488

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